K2C72_MOUSE
ID K2C72_MOUSE Reviewed; 520 AA.
AC Q6IME9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Keratin, type II cytoskeletal 72;
DE AltName: Full=Cytokeratin-72;
DE Short=CK-72;
DE AltName: Full=Keratin-72;
DE Short=K72;
DE AltName: Full=Type II inner root sheath-specific keratin-K6irs2;
DE AltName: Full=Type-II keratin Kb35;
GN Name=Krt72; Synonyms=Kb35, Krt72-ps;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- FUNCTION: Has a role in hair formation. Specific component of keratin
CC intermediate filaments in the inner root sheath (IRS) of the hair
CC follicle (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AC104862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001584; DAA02059.1; -; mRNA.
DR CCDS; CCDS27863.1; -.
DR RefSeq; NP_998893.1; NM_213728.1.
DR AlphaFoldDB; Q6IME9; -.
DR SMR; Q6IME9; -.
DR BioGRID; 222940; 4.
DR STRING; 10090.ENSMUSP00000065922; -.
DR iPTMnet; Q6IME9; -.
DR PhosphoSitePlus; Q6IME9; -.
DR jPOST; Q6IME9; -.
DR PaxDb; Q6IME9; -.
DR PeptideAtlas; Q6IME9; -.
DR PRIDE; Q6IME9; -.
DR ProteomicsDB; 269170; -.
DR Antibodypedia; 55991; 122 antibodies from 21 providers.
DR DNASU; 105866; -.
DR Ensembl; ENSMUST00000071104; ENSMUSP00000065922; ENSMUSG00000056605.
DR GeneID; 105866; -.
DR KEGG; mmu:105866; -.
DR UCSC; uc007xtz.1; mouse.
DR CTD; 140807; -.
DR MGI; MGI:2146034; Krt72.
DR VEuPathDB; HostDB:ENSMUSG00000056605; -.
DR eggNOG; ENOG502T3SC; Eukaryota.
DR GeneTree; ENSGT00940000162105; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q6IME9; -.
DR OMA; CKKRYEV; -.
DR OrthoDB; 671547at2759; -.
DR PhylomeDB; Q6IME9; -.
DR TreeFam; TF317854; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 105866; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q6IME9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6IME9; protein.
DR Bgee; ENSMUSG00000056605; Expressed in lip and 19 other tissues.
DR Genevisible; Q6IME9; MM.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..520
FT /note="Keratin, type II cytoskeletal 72"
FT /id="PRO_0000314878"
FT DOMAIN 134..447
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..133
FT /note="Head"
FT REGION 134..169
FT /note="Coil 1A"
FT REGION 170..188
FT /note="Linker 1"
FT REGION 189..280
FT /note="Coil 1B"
FT REGION 281..304
FT /note="Linker 12"
FT REGION 305..443
FT /note="Coil 2"
FT REGION 444..520
FT /note="Tail"
FT REGION 494..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 385
FT /note="Stutter"
SQ SEQUENCE 520 AA; 56750 MW; BC19F6823BC58B2C CRC64;
MSRQLTLYPG AERLGFSGCS AVISGRLSGS HASVRAGVKG AAFGSRSLFC VGGGRRLALS
SAGRSGGFTL GHGGASGGRP GGFVGTVFGS AGLGPTCPSV CPPGGIPQVV VNKSLLAPLN
VELDPEIQKV RAQEREQIKA LNNKFASFID KVRFLEQQNQ VLETKWELLQ QLDLNNSKRS
LEPVHESYIS NLQKQLEILS GDRVRLDSEL RNMREVVEDC KKRYEVEINR RTAAENEFVV
LKKDVDAAYM NKVELQAKVD SLTDDIKFFK VLFEGEIAQM QSHISDTSVI LSMDNNRQLD
LDSILAEVRA QYEEIAVKSK AETENMYQCK IQELQATAGQ HGDDLKHTKS EITEINRLIQ
RIHSEIGNMK KQCSNLETAI ADAEQRGDCA LKDARAKLDQ LEGALQQAKE ELARMLREHQ
ELMNVKLALD MEIATYRKLL ESEESRMAGE YPNSVSISVI SSTNAGPGGA GFSVGFGASS
SYNYRPLALE VKTKGSCGSE LKDPPAKTSG SSGTTKKTSR
