ID   K2C73_BOVIN             Reviewed;         540 AA.
AC   A7YWK3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Keratin, type II cytoskeletal 73;
DE   AltName: Full=Cytokeratin-73;
DE            Short=CK-73;
DE   AltName: Full=Keratin-73;
DE            Short=K73;
DE   AltName: Full=Type II inner root sheath-specific keratin-K6irs3;
DE   AltName: Full=Type-II keratin Kb36;
GN   Name=KRT73;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has a role in hair formation. Specific component of keratin
CC       intermediate filaments in the inner root sheath (IRS) of the hair
CC       follicle (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC       respectively).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC134633; AAI34634.1; -; mRNA.
DR   RefSeq; NP_001104574.1; NM_001111104.1.
DR   RefSeq; XP_010803212.1; XM_010804910.2.
DR   AlphaFoldDB; A7YWK3; -.
DR   SMR; A7YWK3; -.
DR   STRING; 9913.ENSBTAP00000010393; -.
DR   PaxDb; A7YWK3; -.
DR   PeptideAtlas; A7YWK3; -.
DR   PRIDE; A7YWK3; -.
DR   Ensembl; ENSBTAT00000010393; ENSBTAP00000010393; ENSBTAG00000037638.
DR   GeneID; 531981; -.
DR   KEGG; bta:531981; -.
DR   CTD; 319101; -.
DR   VEuPathDB; HostDB:ENSBTAG00000037638; -.
DR   VGNC; VGNC:30737; KRT73.
DR   eggNOG; ENOG502SK67; Eukaryota.
DR   GeneTree; ENSGT00940000161853; -.
DR   HOGENOM; CLU_012560_6_1_1; -.
DR   InParanoid; A7YWK3; -.
DR   OMA; ARMMCEY; -.
DR   OrthoDB; 671547at2759; -.
DR   TreeFam; TF317854; -.
DR   Reactome; R-BTA-6805567; Keratinization.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000037638; Expressed in zone of skin and 9 other tissues.
DR   GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..540
FT                   /note="Keratin, type II cytoskeletal 73"
FT                   /id="PRO_0000314880"
FT   DOMAIN          132..445
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..131
FT                   /note="Head"
FT   REGION          132..167
FT                   /note="Coil 1A"
FT   REGION          168..186
FT                   /note="Linker 1"
FT   REGION          187..278
FT                   /note="Coil 1B"
FT   REGION          279..302
FT                   /note="Linker 12"
FT   REGION          303..441
FT                   /note="Coil 2"
FT   REGION          442..540
FT                   /note="Tail"
FT   REGION          509..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            383
FT                   /note="Stutter"
SQ   SEQUENCE   540 AA;  58836 MW;  3A6B3DAF9B18C7B0 CRC64;
     MSRQFTYKSG AAAKGAFSGC SVVLSGSSSP SYRAGSKGLS GGFGSRSLYS LGCARSVSFN
     MASGSGRAGG YGFSRGRASG FAGSMFGSVA LGPMCPSLCP PGGIHQVIVN KSLLAPLNVE
     LDPEIQKVCA QEREQIKALN NKFASFIDKV RFLEQQNQVL GTKWELLQQQ DLDNCKNNLE
     PILEGYISNL RKQLEMLSGD RVRLDSELRS MRDVVEDYKK RYEEEINKRT TAENEFVVLK
     KDVDAAYMSK VELQAKVDAL EREIKFFTCL YEGEIAQMQS HISDTSVILS MDNNRNLDLN
     SIIAEVRAQY EDIALKSKAE AEALYQTKFQ ELQLAAGRHG DDLKHTKNEI AELTRLIQRL
     RSETESVKKQ CSNLETAITD AEQRGHCALK DAQAKLDELE AALLQAKEEL ARMMCEYQEL
     MSTKLALDIE IATYRKLLEG EECRMSGEYT NSVSISVISS SMAGTAGTGA GFGYSGSGTY
     GYRPSSVGGG YGFLLGGCVT GSGNCSPRGE AKTRLGSTSE IKDLLGKTPA LSSPTKKTPR