K2C73_MOUSE
ID K2C73_MOUSE Reviewed; 539 AA.
AC Q6NXH9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Keratin, type II cytoskeletal 73;
DE AltName: Full=Cytokeratin-73;
DE Short=CK-73;
DE AltName: Full=Keratin-73;
DE Short=K73;
DE AltName: Full=Type II inner root sheath-specific keratin-K6irs3;
DE AltName: Full=Type-II keratin Kb36;
GN Name=Krt73; Synonyms=Kb36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PROTEIN SEQUENCE OF 151-162; 295-306 AND 424-434, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [3]
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Has a role in hair formation. Specific component of keratin
CC intermediate filaments in the inner root sheath (IRS) of the hair
CC follicle (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; BC067067; AAH67067.1; -; mRNA.
DR EMBL; BK003988; DAA02233.1; -; mRNA.
DR CCDS; CCDS27864.1; -.
DR RefSeq; NP_997650.1; NM_212485.2.
DR AlphaFoldDB; Q6NXH9; -.
DR SMR; Q6NXH9; -.
DR BioGRID; 230210; 13.
DR IntAct; Q6NXH9; 2.
DR MINT; Q6NXH9; -.
DR STRING; 10090.ENSMUSP00000065349; -.
DR iPTMnet; Q6NXH9; -.
DR PhosphoSitePlus; Q6NXH9; -.
DR jPOST; Q6NXH9; -.
DR PaxDb; Q6NXH9; -.
DR PeptideAtlas; Q6NXH9; -.
DR PRIDE; Q6NXH9; -.
DR ProteomicsDB; 269445; -.
DR Antibodypedia; 51267; 112 antibodies from 17 providers.
DR DNASU; 223915; -.
DR Ensembl; ENSMUST00000063292; ENSMUSP00000065349; ENSMUSG00000063661.
DR GeneID; 223915; -.
DR KEGG; mmu:223915; -.
DR UCSC; uc007xua.1; mouse.
DR CTD; 319101; -.
DR MGI; MGI:3607712; Krt73.
DR VEuPathDB; HostDB:ENSMUSG00000063661; -.
DR eggNOG; ENOG502SK67; Eukaryota.
DR GeneTree; ENSGT00940000161853; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q6NXH9; -.
DR OMA; ARMMCEY; -.
DR OrthoDB; 671547at2759; -.
DR PhylomeDB; Q6NXH9; -.
DR TreeFam; TF317854; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 223915; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Krt73; mouse.
DR PRO; PR:Q6NXH9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6NXH9; protein.
DR Bgee; ENSMUSG00000063661; Expressed in hair follicle and 29 other tissues.
DR Genevisible; Q6NXH9; MM.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; Intermediate filament; Keratin;
KW Reference proteome.
FT CHAIN 1..539
FT /note="Keratin, type II cytoskeletal 73"
FT /id="PRO_0000314882"
FT DOMAIN 131..444
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..130
FT /note="Head"
FT REGION 131..166
FT /note="Coil 1A"
FT REGION 167..185
FT /note="Linker 1"
FT REGION 186..277
FT /note="Coil 1B"
FT REGION 278..301
FT /note="Linker 12"
FT REGION 302..440
FT /note="Coil 2"
FT REGION 441..539
FT /note="Tail"
FT SITE 382
FT /note="Stutter"
SQ SEQUENCE 539 AA; 58911 MW; BFE03280203C0A06 CRC64;
MNRQFTCKPG VANRGFSGCS AVLSGGSSSS YRAAGKGLSG GFSSRSLYSL RSPRSISFNV
ASSSGRTGGY GFGRNRASGF AGSMFGSGAL GPSNPSLCLP GGIHQVTVNK SLLAPLNVEL
DPEIQKVRAQ EREQIKALNN KFASFIDKVR FLEQQNQVLQ TKWELLQQLD LSNCRRNLEP
VYEAHISSLQ KQLDSLSGDR VRLDSELRGM RDAVEDCKKR YEEEINKRTT AENEFVVLKK
DVDAAYMSKV ELQAKVDALD GEIKFLKCLY EGEITQMQSH ISDTSVVLSM DNNRNLDLDS
IIAEVRAQYE DIALKSKAEA EMVYQTKFQE LQLAAGRHGD DLKHTRNEIS ELTRLIQRLR
SEIESVKKQC SNLETAIADA EQRGDCALKD ARAKLDELER ALHQAKEELA RMLREHQELM
SMKLALDIEI ATYRKLLEGE ECRMSGEHTS AVSISVISSS APGTVGAGTS FGFSSAGTYG
YRQSSVAGGY GILSGGCVTG SGNCSPRGDT KNRLGSASEF KEVSGKTLAL GSPSKKTMR
