K2C73_RAT
ID K2C73_RAT Reviewed; 553 AA.
AC Q6IG03;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Keratin, type II cytoskeletal 73;
DE AltName: Full=Cytokeratin-73;
DE Short=CK-73;
DE AltName: Full=Keratin-73;
DE Short=K73;
DE AltName: Full=Type II inner root sheath-specific keratin-K6irs3;
DE AltName: Full=Type-II keratin Kb36;
GN Name=Krt73; Synonyms=Kb36;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP PROTEIN SEQUENCE OF 151-162, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RA Lubec G., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [3]
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- FUNCTION: Has a role in hair formation. Specific component of keratin
CC intermediate filaments in the inner root sheath (IRS) of the hair
CC follicle (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA02227.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AABR03055962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK003982; DAA02227.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001008808.1; NM_001008808.1.
DR AlphaFoldDB; Q6IG03; -.
DR SMR; Q6IG03; -.
DR STRING; 10116.ENSRNOP00000013122; -.
DR iPTMnet; Q6IG03; -.
DR PhosphoSitePlus; Q6IG03; -.
DR jPOST; Q6IG03; -.
DR PaxDb; Q6IG03; -.
DR PRIDE; Q6IG03; -.
DR GeneID; 300248; -.
DR KEGG; rno:300248; -.
DR UCSC; RGD:1359597; rat.
DR CTD; 319101; -.
DR RGD; 1359597; Krt73.
DR VEuPathDB; HostDB:ENSRNOG00000025087; -.
DR eggNOG; ENOG502SK67; Eukaryota.
DR InParanoid; Q6IG03; -.
DR OMA; ARMMCEY; -.
DR OrthoDB; 671547at2759; -.
DR PhylomeDB; Q6IG03; -.
DR Reactome; R-RNO-6805567; Keratinization.
DR Reactome; R-RNO-6809371; Formation of the cornified envelope.
DR PRO; PR:Q6IG03; -.
DR Proteomes; UP000002494; Chromosome 7.
DR ExpressionAtlas; Q6IG03; differential.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; Intermediate filament; Keratin;
KW Reference proteome.
FT CHAIN 1..553
FT /note="Keratin, type II cytoskeletal 73"
FT /id="PRO_0000314883"
FT DOMAIN 131..444
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..130
FT /note="Head"
FT REGION 131..166
FT /note="Coil 1A"
FT REGION 167..185
FT /note="Linker 1"
FT REGION 186..277
FT /note="Coil 1B"
FT REGION 278..301
FT /note="Linker 12"
FT REGION 302..440
FT /note="Coil 2"
FT REGION 441..539
FT /note="Tail"
FT SITE 382
FT /note="Stutter"
SQ SEQUENCE 553 AA; 60387 MW; B5DF12D7A676EC5F CRC64;
MNRQFTCKSG AANRGFSGCS AVLSGGSASS YRAGGKGLGG GFSSRSLYSL RSPRSISFNV
ASGSGRTGGY GFGRNRASGF AGSMFGGGAL GPSNPSLCLP GGIHQVTVNK SLLAPLNVEL
DPEIQKVRAQ EREQIKALNN KFASFIDKVR FLEQQNQVLQ TKWELLQQLD LSNCRRNLEP
VYEAHISSLQ KQLDSLSGDR VRLDSELRGM RDAVEDCKKR YEEEINKRTT AENEFVVLKK
DVDAAYMSKV ELQAKVDALD GEIKFLKCLY EGEITQMQSH ISDTSVVLSM DNNRNLDLDS
IIAEVRAQYE DIALKSKAEA EMVYQTKFQE LQLAAGRHGD DLKHTRNEIS ELTRLIQRLR
SEIESVKKQC SNLETAIADA EQRGDCALKD AQAKLDDLER ALHQAKEELA RMLREHQELM
SMKLALDIEI ATYRKLLEGE ECRMSGEHTN AVSISVISSS TTGAVGAGTS FGFSNPSTYG
YRPSSVAGGY GILSGGCVTG SGNCSPRGDT KTRLGSASEF KEVSGKTLAL GSPSKKTMRA
DRQSSISVQL WFS
