ID   K2C74_BOVIN             Reviewed;         550 AA.
AC   A3KN27;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Keratin, type II cytoskeletal 74;
DE   AltName: Full=Cytokeratin-74;
DE            Short=CK-74;
DE   AltName: Full=Keratin-74;
DE            Short=K74;
DE   AltName: Full=Type II inner root sheath-specific keratin-K6irs4;
DE   AltName: Full=Type-II keratin Kb37;
GN   Name=KRT74;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has a role in hair formation. Specific component of keratin
CC       intermediate filaments in the inner root sheath (IRS) of the hair
CC       follicle (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC       respectively).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC133518; AAI33519.1; -; mRNA.
DR   RefSeq; NP_001076916.1; NM_001083447.1.
DR   AlphaFoldDB; A3KN27; -.
DR   SMR; A3KN27; -.
DR   STRING; 9913.ENSBTAP00000038264; -.
DR   PaxDb; A3KN27; -.
DR   PeptideAtlas; A3KN27; -.
DR   PRIDE; A3KN27; -.
DR   Ensembl; ENSBTAT00000038451; ENSBTAP00000038264; ENSBTAG00000000619.
DR   GeneID; 525034; -.
DR   KEGG; bta:525034; -.
DR   CTD; 121391; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000619; -.
DR   VGNC; VGNC:30738; KRT74.
DR   eggNOG; ENOG502RNQG; Eukaryota.
DR   GeneTree; ENSGT00940000162774; -.
DR   InParanoid; A3KN27; -.
DR   OMA; QRIRCDI; -.
DR   OrthoDB; 671547at2759; -.
DR   TreeFam; TF317854; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000000619; Expressed in zone of skin and 8 other tissues.
DR   ExpressionAtlas; A3KN27; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR   GO; GO:1990254; F:keratin filament binding; IEA:Ensembl.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..550
FT                   /note="Keratin, type II cytoskeletal 74"
FT                   /id="PRO_0000314884"
FT   DOMAIN          141..468
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..140
FT                   /note="Head"
FT   REGION          141..176
FT                   /note="Coil 1A"
FT   REGION          177..195
FT                   /note="Linker 1"
FT   REGION          196..287
FT                   /note="Coil 1B"
FT   REGION          288..311
FT                   /note="Linker 12"
FT   REGION          312..464
FT                   /note="Coil 2"
FT   REGION          465..550
FT                   /note="Tail"
FT   REGION          491..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..523
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..540
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            406
FT                   /note="Stutter"
SQ   SEQUENCE   550 AA;  59952 MW;  D53A697671118456 CRC64;
     MSRQLNIKSG GDKGGFSGHS AVVLRKVGGS AASYRAPSKG AGAAFGSRSL YSLCRGDLCV
     PLKVAGSSVR TGGYNFRLGS GYGGVRASSF AGSMFGSVVL GPVCPSMCPP GGIHQVTVNK
     SLLAPLNVEL DPEIQKVRAQ EREQIMALNN KFASFIDKVR FLEQQNQVLG TKWELLQQMD
     LNNCRKNLEP ILEGYIGNLR KQLEMLSGDR LRLDSELKGM RDLVEDYKKR YEVEINQRTA
     AENDFVVLKK DADAAYTVKV ELQAKVDSLD KDIKFLKCLY DAEVAQIQTH TSETSVILSM
     DNNRYLDLDS IIAEVRAQYE DIALKSKAEA EALYQSKIQE LQLAAGRHGD DLKHTKNEMS
     ELNRLIQRIR CEIANVKKQA FSVCSKPAPC PLQCANLETA IADAEQRGDS ALKDARAKLD
     ELEAAMHQAK EELARMLREY QELMSLKLAL DMEIATYSKL LEGEECWMSG ENPSSVSISV
     ISSSASSFGY HPGSSASTDL GASTMASTGT SSSSSTQSGQ TRAKGARVGD PKDSQDKSTP
     VSSRARKAAR