ID   K2C75_BOVIN             Reviewed;         543 AA.
AC   Q08D91;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Keratin, type II cytoskeletal 75;
DE   AltName: Full=Cytokeratin-75;
DE            Short=CK-75;
DE   AltName: Full=Keratin-6 hair follicle;
DE   AltName: Full=Keratin-75;
DE            Short=K75;
DE   AltName: Full=Type II keratin-K6hf;
DE   AltName: Full=Type-II keratin Kb18;
GN   Name=KRT75;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a central role in hair and nail formation. Essential
CC       component of keratin intermediate filaments in the companion layer of
CC       the hair follicle (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a type I and a type II keratin. May associate
CC       with KRT17. {ECO:0000250}.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC       respectively).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC123881; AAI23882.1; -; mRNA.
DR   RefSeq; NP_001070385.1; NM_001076917.1.
DR   AlphaFoldDB; Q08D91; -.
DR   SMR; Q08D91; -.
DR   IntAct; Q08D91; 1.
DR   STRING; 9913.ENSBTAP00000038262; -.
DR   PaxDb; Q08D91; -.
DR   PeptideAtlas; Q08D91; -.
DR   PRIDE; Q08D91; -.
DR   Ensembl; ENSBTAT00000038449; ENSBTAP00000038262; ENSBTAG00000016121.
DR   GeneID; 539683; -.
DR   KEGG; bta:539683; -.
DR   CTD; 9119; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016121; -.
DR   VGNC; VGNC:30739; KRT75.
DR   eggNOG; ENOG502RTYA; Eukaryota.
DR   GeneTree; ENSGT00940000155862; -.
DR   HOGENOM; CLU_012560_6_1_1; -.
DR   InParanoid; Q08D91; -.
DR   OMA; RMFFEAE; -.
DR   OrthoDB; 824246at2759; -.
DR   TreeFam; TF317854; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000016121; Expressed in zone of skin and 21 other tissues.
DR   ExpressionAtlas; Q08D91; baseline.
DR   GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR   GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..543
FT                   /note="Keratin, type II cytoskeletal 75"
FT                   /id="PRO_0000314886"
FT   DOMAIN          145..458
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..144
FT                   /note="Head"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..180
FT                   /note="Coil 1A"
FT   REGION          181..199
FT                   /note="Linker 1"
FT   REGION          200..292
FT                   /note="Coil 1B"
FT   REGION          293..315
FT                   /note="Linker 12"
FT   REGION          316..454
FT                   /note="Coil 2"
FT   REGION          455..543
FT                   /note="Tail"
FT   REGION          511..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            396
FT                   /note="Stutter"
SQ   SEQUENCE   543 AA;  59036 MW;  8DA005DCCA94BA0C CRC64;
     MSRQSTITFQ TSSRRGFSTA SATTPATSRS RFSSASVTHS PAGSGGLGRI SGFGSRSLYN
     LGGTKRVSIS GCGSNFRSGF GGRASSGFGV SGGFGYGGGI GGGHGGCGFS VCPPGGIQEV
     TVNQSLLTPL NLQIDPNIQR VRKEEREQIK TLNNKFASFI DKVRFLEQQN KVLETKWSLL
     QEQGTRTVRQ SLEPFFEAYI TDLRRQLDSI TTERGRLDAE LRTMQDVVED FKVRYEDEIN
     KRTAAENEFV ALKKDVDAAY LNKVDLEAKA NSLTDEINFL QMLFEAELCQ MQTRVSDTSV
     VLSMDNNRSL DLDSIIAEVK AQYEEIANRS RAEAESWYQT KYEELQVTAG QHGDDLRNTK
     QEISETNRMI QRLRAEIDNV KKQCASLQTA IADAEQRGEL ALKDARAKLV DLEEALQKSK
     QDMARLLREY QELMNIKLAL DVEIATYRKL LEGEECRLSG EGVSPVNISV VTSTVSSGYG
     GGSSIGSGSL GLSGGSGCSF MTSGGHSLGG SSFSNSSSRG LGGSGSSFKF VSTTSSSRKS
     YKH