K2C75_RAT
ID K2C75_RAT Reviewed; 542 AA.
AC Q6IG05;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Keratin, type II cytoskeletal 75;
DE AltName: Full=Cytokeratin-75;
DE Short=CK-75;
DE AltName: Full=Keratin-6 hair follicle;
DE AltName: Full=Keratin-75;
DE Short=K75;
DE AltName: Full=Type II keratin-K6hf;
DE AltName: Full=Type-II keratin Kb18;
GN Name=Krt75; Synonyms=Kb18;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- FUNCTION: Plays a central role in hair and nail formation. Essential
CC component of keratin intermediate filaments in the companion layer of
CC the hair follicle (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of a type I and a type II keratin. May associate
CC with KRT17. {ECO:0000250}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AABR03056237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK003980; DAA02225.1; -; mRNA.
DR RefSeq; NP_001008828.1; NM_001008828.1.
DR RefSeq; XP_006242387.1; XM_006242325.3.
DR AlphaFoldDB; Q6IG05; -.
DR SMR; Q6IG05; -.
DR BioGRID; 256508; 1.
DR STRING; 10116.ENSRNOP00000012640; -.
DR iPTMnet; Q6IG05; -.
DR PhosphoSitePlus; Q6IG05; -.
DR jPOST; Q6IG05; -.
DR PaxDb; Q6IG05; -.
DR PRIDE; Q6IG05; -.
DR Ensembl; ENSRNOT00000088923; ENSRNOP00000070762; ENSRNOG00000043203.
DR GeneID; 300247; -.
DR KEGG; rno:300247; -.
DR UCSC; RGD:1359576; rat.
DR CTD; 9119; -.
DR RGD; 1359576; Krt75.
DR eggNOG; ENOG502RTYA; Eukaryota.
DR GeneTree; ENSGT00940000155862; -.
DR InParanoid; Q6IG05; -.
DR OrthoDB; 824246at2759; -.
DR PhylomeDB; Q6IG05; -.
DR TreeFam; TF317854; -.
DR Reactome; R-RNO-6805567; Keratinization.
DR Reactome; R-RNO-6809371; Formation of the cornified envelope.
DR PRO; PR:Q6IG05; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000043203; Expressed in thymus and 5 other tissues.
DR ExpressionAtlas; Q6IG05; baseline and differential.
DR Genevisible; Q6IG05; RN.
DR GO; GO:0001533; C:cornified envelope; ISO:RGD.
DR GO; GO:0005882; C:intermediate filament; ISO:RGD.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 2.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..542
FT /note="Keratin, type II cytoskeletal 75"
FT /id="PRO_0000314889"
FT DOMAIN 140..453
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..139
FT /note="Head"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..175
FT /note="Coil 1A"
FT REGION 176..194
FT /note="Linker 1"
FT REGION 195..287
FT /note="Coil 1B"
FT REGION 288..310
FT /note="Linker 12"
FT REGION 311..449
FT /note="Coil 2"
FT REGION 450..542
FT /note="Tail"
FT REGION 514..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 391
FT /note="Stutter"
SQ SEQUENCE 542 AA; 59027 MW; 5600853834F37EFC CRC64;
MSRQSTVTFH SGSRRGFSTA SATTPTAGRS RFSSVSVARS SGNSGGLGRI SGIGSGFGSR
SLYNLGATRP VSVGGCAGSG FRSGFGGRAS SSFGYGGGFG GPGFPVCPSG SIQEVTVNQS
LLTPLNLQID PTIQRVRKEE REQIKTLNNK FASFIDKVRF LEQQNKVLET KWNLLQEQGS
RTVRQNLEPF FDAYVNDLRR QLDSVTAERG RLDAELRHMQ EVVEDFKVRY EDEINKRAAA
ENEFVGLKKD VDGAYMNKVE LEAKVDSLTD QINFYRMVYE AELSQMQNQV SDTSVVLSMD
NNRSLDLDSI IAEVKAQYED IANRSRAEAE SWYQTKYEEL QVTAGRHGDD LRNTKQEISE
MNRMIQRLRS EIDAVKKQCS SLQTAISDTE QRGELALKDA RAKLVELEDA LQKAKQDMAR
LLREYQELMN VKLALDVEIA TYRKLLEGEE CRLSGEGVSP VNISVVTSTV SSGYGGGTNI
GGGSLGLGGN SGYSFTTTGG HSLGTGLGGS GFTTSSSRGP VGSGSSIKFV SSTSSSRKSY
KH
