ID   K2C78_BOVIN             Reviewed;         528 AA.
AC   A6QNX5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Keratin, type II cytoskeletal 78;
DE   AltName: Full=Cytokeratin-78;
DE            Short=CK-78;
DE   AltName: Full=Keratin-78;
DE            Short=K78;
DE   AltName: Full=Type-II keratin Kb40;
GN   Name=KRT78;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC       respectively).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC149049; AAI49050.1; -; mRNA.
DR   RefSeq; NP_001095547.1; NM_001102077.1.
DR   AlphaFoldDB; A6QNX5; -.
DR   SMR; A6QNX5; -.
DR   STRING; 9913.ENSBTAP00000000815; -.
DR   PaxDb; A6QNX5; -.
DR   PeptideAtlas; A6QNX5; -.
DR   PRIDE; A6QNX5; -.
DR   Ensembl; ENSBTAT00000000815; ENSBTAP00000000815; ENSBTAG00000039967.
DR   GeneID; 523221; -.
DR   KEGG; bta:523221; -.
DR   CTD; 196374; -.
DR   VEuPathDB; HostDB:ENSBTAG00000039967; -.
DR   VGNC; VGNC:30740; KRT78.
DR   eggNOG; ENOG502SPJX; Eukaryota.
DR   GeneTree; ENSGT00940000162461; -.
DR   HOGENOM; CLU_012560_6_1_1; -.
DR   InParanoid; A6QNX5; -.
DR   OMA; GSRGSTW; -.
DR   OrthoDB; 824246at2759; -.
DR   TreeFam; TF317854; -.
DR   Reactome; R-BTA-6805567; Keratinization.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000039967; Expressed in esophagus and 37 other tissues.
DR   GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..528
FT                   /note="Keratin, type II cytoskeletal 78"
FT                   /id="PRO_0000314890"
FT   DOMAIN          105..418
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..104
FT                   /note="Head"
FT   REGION          23..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..140
FT                   /note="Coil 1A"
FT   REGION          141..159
FT                   /note="Linker 1"
FT   REGION          160..252
FT                   /note="Coil 1B"
FT   REGION          253..275
FT                   /note="Linker 12"
FT   REGION          276..415
FT                   /note="Coil 2"
FT   REGION          416..528
FT                   /note="Tail"
FT   COMPBIAS        23..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            356
FT                   /note="Stutter"
SQ   SEQUENCE   528 AA;  57464 MW;  F0AB6E80013185AA CRC64;
     MSLSPCRARR GFSARSACSA QSVGRGRTGF SSRSLSSFGG CRGGSRGRTW GSWGRLGVRL
     GEGSGGPGLS LCPPGGIQQV TINQSLLIPP KIEIDPQFQV VRTQETQQIR VLNNQFASFI
     DKVRFLEQQN KVLETKWHLL QQQGLSDRPQ GLESFFEAYL VRLRTQLEEL QKKRGSLDAE
     LKSCQGQEEE YKAKYEHEAN RRATLENDFV VLKKDADGVL LSKMEMESKV EDLKEYICFL
     KHLYEEELGQ LQTQASDMSV VLSMDNNRCL DFRDLIAEVR ARYEEIARTS KAEAEMLYQT
     KYRELQACAQ LHGNSMKETK VQITQLQQTI KKLQSQIETV KSQNASLQVA IADAEQRGEL
     ALKDAQTKLA ELEAALRTAK QDIARLLHDY QELMSVKLSL DIEIATYRRL LEGEECRMSG
     ECASQVTISV GGGSTVVSGG ADGGLAGTCG LGGVKGSFGS RCSSVVKGGS SIVKGGSSVV
     IGGSSIILGS EQGPAVGSGS VSGSSSSSTS HTILKKTVES SLKTSVTY