K2C79_BOVIN
ID K2C79_BOVIN Reviewed; 535 AA.
AC Q148H7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Keratin, type II cytoskeletal 79;
DE AltName: Full=Cytokeratin-79;
DE Short=CK-79;
DE AltName: Full=Keratin-79;
DE Short=K79;
DE AltName: Full=Type-II keratin Kb38;
GN Name=KRT79;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; BC118314; AAI18315.1; -; mRNA.
DR RefSeq; NP_001068816.1; NM_001075348.1.
DR AlphaFoldDB; Q148H7; -.
DR SMR; Q148H7; -.
DR IntAct; Q148H7; 1.
DR STRING; 9913.ENSBTAP00000016839; -.
DR PaxDb; Q148H7; -.
DR PeptideAtlas; Q148H7; -.
DR PRIDE; Q148H7; -.
DR GeneID; 508202; -.
DR KEGG; bta:508202; -.
DR CTD; 338785; -.
DR eggNOG; ENOG502SPJX; Eukaryota.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q148H7; -.
DR OrthoDB; 824246at2759; -.
DR TreeFam; TF317854; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 2.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..535
FT /note="Keratin, type II cytoskeletal 79"
FT /id="PRO_0000314892"
FT DOMAIN 142..457
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..141
FT /note="Head"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..177
FT /note="Coil 1A"
FT REGION 178..198
FT /note="Linker 1"
FT REGION 199..290
FT /note="Coil 1B"
FT REGION 291..314
FT /note="Linker 12"
FT REGION 315..453
FT /note="Coil 2"
FT REGION 454..535
FT /note="Tail"
FT COMPBIAS 1..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 395
FT /note="Stutter"
SQ SEQUENCE 535 AA; 57721 MW; 67540343FF24834F CRC64;
MRSSVSRQTY STKGAFSSSS ASGGGGSQAR TSFSSVTVSR NSGRGGGPRC GPSMGGFGSQ
SLYNLGGSKS ISVSVAGGAS AGRVLGGFGL GGGAYMGLGA CRPMLGPVCP PGGIQQVTVN
QSLLTPLHVE IDPEIQRVRT EEREQIKTLN NKFASFIDKV RFLEQQNKVL ETKWALLQEQ
GQKSGVTRNN LEPLFEHFIN NLRGKLDNLQ SERGRLDSEL RNVQDLAEDF KTKYEDEINK
RTAAENEFVV LKKDVDAAYV GRMDLHGMVD HLMGEIDFLR HLYEEELSQV QTHVSDTSVI
LSMDNNRNLD LDSIIAEVKA QYEQIAQRSR AEAESWYQTK YEELQVTAGK HGDNLRDTKN
EIAELTRTVQ RLQGEADAVK KQCQQLQTAI ADAEQHGELA LKDAQKKLGD LDAALNQAKE
DLARLLRDYQ ALMNVKLALD VEIATYRKLL ESEESRMSGE CPSAVSISVT GNSTTVCGGG
AAGFGGGISL GGGGGASKGR FSTNAGYSTV KGGPVSGGTS ILRKTTTVKT SSRRY
