K2C79_HUMAN
ID K2C79_HUMAN Reviewed; 535 AA.
AC Q5XKE5; Q6P465; Q7Z793;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Keratin, type II cytoskeletal 79;
DE AltName: Full=Cytokeratin-79;
DE Short=CK-79;
DE AltName: Full=Keratin-6-like;
DE Short=Keratin-6L;
DE AltName: Full=Keratin-79;
DE Short=K79;
DE AltName: Full=Type-II keratin Kb38;
GN Name=KRT79; Synonyms=K6L, KB38, KRT6L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Skin;
RX PubMed=15737194; DOI=10.1111/j.0022-202x.2004.23530.x;
RA Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J.;
RT "Characterization of new members of the human type II keratin gene family
RT and a general evaluation of the keratin gene domain on chromosome
RT 12q13.13.";
RL J. Invest. Dermatol. 124:536-544(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-81.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-81 AND LEU-195.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=11683385; DOI=10.1242/jcs.114.14.2569;
RA Hesse M., Magin T.M., Weber K.;
RT "Genes for intermediate filament proteins and the draft sequence of the
RT human genome: novel keratin genes and a surprisingly high number of
RT pseudogenes related to keratin genes 8 and 18.";
RL J. Cell Sci. 114:2569-2575(2001).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- INTERACTION:
CC Q5XKE5; Q96CN4: EVI5L; NbExp=3; IntAct=EBI-2514135, EBI-749523;
CC Q5XKE5; A1A4E9: KRT13; NbExp=3; IntAct=EBI-2514135, EBI-10171552;
CC Q5XKE5; P02533: KRT14; NbExp=3; IntAct=EBI-2514135, EBI-702178;
CC Q5XKE5; P19012: KRT15; NbExp=7; IntAct=EBI-2514135, EBI-739566;
CC Q5XKE5; P08779: KRT16; NbExp=3; IntAct=EBI-2514135, EBI-356410;
CC Q5XKE5; P05783: KRT18; NbExp=3; IntAct=EBI-2514135, EBI-297888;
CC Q5XKE5; P08727: KRT19; NbExp=3; IntAct=EBI-2514135, EBI-742756;
CC Q5XKE5; Q2M2I5: KRT24; NbExp=3; IntAct=EBI-2514135, EBI-2952736;
CC Q5XKE5; Q7Z3Z0: KRT25; NbExp=3; IntAct=EBI-2514135, EBI-11980019;
CC Q5XKE5; Q7Z3Y8: KRT27; NbExp=4; IntAct=EBI-2514135, EBI-3044087;
CC Q5XKE5; Q7Z3Y7: KRT28; NbExp=3; IntAct=EBI-2514135, EBI-11980489;
CC Q5XKE5; Q15323: KRT31; NbExp=6; IntAct=EBI-2514135, EBI-948001;
CC Q5XKE5; Q14525: KRT33B; NbExp=8; IntAct=EBI-2514135, EBI-1049638;
CC Q5XKE5; O76011: KRT34; NbExp=3; IntAct=EBI-2514135, EBI-1047093;
CC Q5XKE5; Q92764: KRT35; NbExp=3; IntAct=EBI-2514135, EBI-1058674;
CC Q5XKE5; O76013-2: KRT36; NbExp=3; IntAct=EBI-2514135, EBI-11958506;
CC Q5XKE5; O76015: KRT38; NbExp=6; IntAct=EBI-2514135, EBI-1047263;
CC Q5XKE5; A1L190: SYCE3; NbExp=3; IntAct=EBI-2514135, EBI-10283466;
CC Q5XKE5; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-2514135, EBI-2130429;
CC Q5XKE5; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-2514135, EBI-739895;
CC -!- TISSUE SPECIFICITY: Expressed in skeletal muscle, skin and scalp, but
CC not in any other tissues or organs examined.
CC {ECO:0000269|PubMed:15737194}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AJ564105; CAD91893.1; -; mRNA.
DR EMBL; AC107016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471054; EAW96648.1; -; Genomic_DNA.
DR EMBL; BC039148; AAH39148.1; -; mRNA.
DR EMBL; BC063648; AAH63648.1; -; mRNA.
DR EMBL; BK000976; DAA00403.1; -; Genomic_DNA.
DR CCDS; CCDS8839.1; -.
DR RefSeq; NP_787028.1; NM_175834.2.
DR AlphaFoldDB; Q5XKE5; -.
DR SMR; Q5XKE5; -.
DR BioGRID; 130796; 48.
DR IntAct; Q5XKE5; 31.
DR MINT; Q5XKE5; -.
DR STRING; 9606.ENSP00000328358; -.
DR GlyGen; Q5XKE5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5XKE5; -.
DR PhosphoSitePlus; Q5XKE5; -.
DR SwissPalm; Q5XKE5; -.
DR BioMuta; KRT79; -.
DR DMDM; 296434550; -.
DR EPD; Q5XKE5; -.
DR jPOST; Q5XKE5; -.
DR MassIVE; Q5XKE5; -.
DR PaxDb; Q5XKE5; -.
DR PeptideAtlas; Q5XKE5; -.
DR PRIDE; Q5XKE5; -.
DR ProteomicsDB; 65826; -.
DR Antibodypedia; 26699; 119 antibodies from 16 providers.
DR DNASU; 338785; -.
DR Ensembl; ENST00000330553.6; ENSP00000328358.5; ENSG00000185640.6.
DR GeneID; 338785; -.
DR KEGG; hsa:338785; -.
DR MANE-Select; ENST00000330553.6; ENSP00000328358.5; NM_175834.3; NP_787028.1.
DR UCSC; uc001sbb.4; human.
DR CTD; 338785; -.
DR GeneCards; KRT79; -.
DR HGNC; HGNC:28930; KRT79.
DR HPA; ENSG00000185640; Tissue enriched (skin).
DR MIM; 611160; gene.
DR neXtProt; NX_Q5XKE5; -.
DR OpenTargets; ENSG00000185640; -.
DR PharmGKB; PA162393725; -.
DR VEuPathDB; HostDB:ENSG00000185640; -.
DR eggNOG; ENOG502SPJX; Eukaryota.
DR GeneTree; ENSGT00940000161881; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q5XKE5; -.
DR OMA; YMGQMDL; -.
DR OrthoDB; 824246at2759; -.
DR PhylomeDB; Q5XKE5; -.
DR TreeFam; TF317854; -.
DR PathwayCommons; Q5XKE5; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5XKE5; -.
DR BioGRID-ORCS; 338785; 24 hits in 1070 CRISPR screens.
DR GeneWiki; KRT79; -.
DR GenomeRNAi; 338785; -.
DR Pharos; Q5XKE5; Tbio.
DR PRO; PR:Q5XKE5; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q5XKE5; protein.
DR Bgee; ENSG00000185640; Expressed in upper leg skin and 62 other tissues.
DR ExpressionAtlas; Q5XKE5; baseline and differential.
DR Genevisible; Q5XKE5; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..535
FT /note="Keratin, type II cytoskeletal 79"
FT /id="PRO_0000314893"
FT DOMAIN 142..457
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..141
FT /note="Head"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..177
FT /note="Coil 1A"
FT REGION 178..198
FT /note="Linker 1"
FT REGION 199..290
FT /note="Coil 1B"
FT REGION 291..314
FT /note="Linker 12"
FT REGION 315..453
FT /note="Coil 2"
FT REGION 454..535
FT /note="Tail"
FT COMPBIAS 1..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 395
FT /note="Stutter"
FT VARIANT 81
FT /note="L -> S (in dbSNP:rs2638497)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_038113"
FT VARIANT 195
FT /note="F -> L (in dbSNP:rs17855862)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_038114"
FT VARIANT 266
FT /note="H -> R (in dbSNP:rs17688672)"
FT /id="VAR_038115"
FT VARIANT 393
FT /note="A -> V (in dbSNP:rs17688627)"
FT /id="VAR_038116"
SQ SEQUENCE 535 AA; 57836 MW; B25A71327186A1C4 CRC64;
MRSSVSRQTY STKGGFSSNS ASGGSGSQAR TSFSSVTVSR SSGSGGGAHC GPGTGGFGSR
SLYNLGGHKS ISVSVAGGAL LGRALGGFGF GSRAFMGQGA GRQTFGPACP PGGIQEVTVN
QSLLTPLHVE IDPEIQRVRT QEREQIKTLN NKFASFIDKV RFLEQQNKVL ETKWALLQEQ
GQNLGVTRNN LEPLFEAYLG SMRSTLDRLQ SERGRLDSEL RNVQDLVEDF KNKYEDEINK
HTAAENEFVV LKKDVDAAYM GRMDLHGKVG TLTQEIDFLQ QLYEMELSQV QTHVSNTNVV
LSMDNNRNLD LDSIIAEVKA QYELIAQRSR AEAEAWYQTK YEELQVTAGK HGDNLRDTKN
EIAELTRTIQ RLQGEADAAK KQCQQLQTAI AEAEQRGELA LKDAQKKLGD LDVALHQAKE
DLTRLLRDYQ ELMNVKLALD VEIATYRKLL ESEESRMSGE CPSAVSISVT GNSTTVCGGG
AASFGGGISL GGSGGATKGG FSTNVGYSTV KGGPVSAGTS ILRKTTTVKT SSQRY
