K2C79_MOUSE
ID K2C79_MOUSE Reviewed; 531 AA.
AC Q8VED5; Q8K2E4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Keratin, type II cytoskeletal 79;
DE AltName: Full=Cytokeratin-79;
DE Short=CK-79;
DE AltName: Full=Keratin-79;
DE Short=K79;
DE AltName: Full=Type-II keratin Kb38;
GN Name=Krt79; Synonyms=Kb38;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; BC019155; AAH19155.2; -; mRNA.
DR EMBL; BC031593; AAH31593.1; -; mRNA.
DR CCDS; CCDS27867.1; -.
DR RefSeq; NP_666175.1; NM_146063.1.
DR AlphaFoldDB; Q8VED5; -.
DR SMR; Q8VED5; -.
DR BioGRID; 230211; 10.
DR IntAct; Q8VED5; 1.
DR STRING; 10090.ENSMUSP00000023799; -.
DR iPTMnet; Q8VED5; -.
DR PhosphoSitePlus; Q8VED5; -.
DR CPTAC; non-CPTAC-3978; -.
DR jPOST; Q8VED5; -.
DR PaxDb; Q8VED5; -.
DR PeptideAtlas; Q8VED5; -.
DR PRIDE; Q8VED5; -.
DR ProteomicsDB; 269057; -.
DR Antibodypedia; 26699; 119 antibodies from 16 providers.
DR DNASU; 223917; -.
DR Ensembl; ENSMUST00000023799; ENSMUSP00000023799; ENSMUSG00000061397.
DR GeneID; 223917; -.
DR KEGG; mmu:223917; -.
DR UCSC; uc007xug.1; mouse.
DR CTD; 338785; -.
DR MGI; MGI:2385030; Krt79.
DR VEuPathDB; HostDB:ENSMUSG00000061397; -.
DR eggNOG; ENOG502SPJX; Eukaryota.
DR GeneTree; ENSGT00940000161881; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR InParanoid; Q8VED5; -.
DR OMA; YMGQMDL; -.
DR OrthoDB; 824246at2759; -.
DR PhylomeDB; Q8VED5; -.
DR TreeFam; TF317854; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 223917; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8VED5; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8VED5; protein.
DR Bgee; ENSMUSG00000061397; Expressed in lip and 63 other tissues.
DR Genevisible; Q8VED5; MM.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 2.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..531
FT /note="Keratin, type II cytoskeletal 79"
FT /id="PRO_0000314894"
FT DOMAIN 139..453
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..138
FT /note="Head"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..174
FT /note="Coil 1A"
FT REGION 175..194
FT /note="Linker 1"
FT REGION 195..286
FT /note="Coil 1B"
FT REGION 287..310
FT /note="Linker 12"
FT REGION 311..449
FT /note="Coil 2"
FT REGION 450..531
FT /note="Tail"
FT SITE 391
FT /note="Stutter"
SQ SEQUENCE 531 AA; 57552 MW; F3D9893938F72BF7 CRC64;
MRSSLSRQTF STKGGFSSNS ASGGGGSRMR TSYSSVTMSR GSGGGGGVRS GSSSGGFGSR
SLYNLGGKNI SVSMACGASS GRALGGFGSG AYVGLGASRQ TFGPVCPPGG IQEVTVNQSL
LTPLNVEIDP EIQRVRTQER EQIKTLNNKF ASFIDKVRFL EQQNKVLETK WALLQEQSQN
TGVARSLEPF FENYLSTLRR QLDTKQSERG RLDMELRNVQ DNLEDFKNKY EDEINKRTAL
ENEFVLLKKD VDAAYMGRMD LHGKVDSLTQ EIDFLQQLFE MELSQVQTNV SDTNVILSMD
NNRNLDLDSI IAEVKAQYEL IAQKSRAEAE SWYQTKYEEL QVTAGKHGDS LRDTKNEIAE
LTRTTQRLQG EVDAAKKQCQ QLQTAIAEAE QNGEMALKDA KKKLGDLDTA LHQAKEDLAR
MLREYQDLVS VKLALDMEIA TYRKLLESEE SRMSGDCPSA ISISVTGNST SVCAGGTAGF
GNGLSLGGAG GASKGGFGSS VSYGAAKGGQ VSGGTSILRK TTTVKTSSRR Y
