ID   K2C7_XENLA              Reviewed;         513 AA.
AC   P16878;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Keratin, type II cytoskeletal 7;
DE   AltName: Full=XENCK55(5/6);
GN   Name=krt7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=2478354; DOI=10.1242/dev.104.4.533;
RA   Fouquet B., Herrmann H., Franz J.K., Franke W.W.;
RT   "Expression of intermediate filament proteins during development of Xenopus
RT   laevis. III. Identification of mRNAs encoding cytokeratins typical of
RT   complex epithelia.";
RL   Development 104:533-548(1988).
CC   -!- FUNCTION: Blocks interferon-dependent interphase and stimulates DNA
CC       synthesis in cells. {ECO:0000250|UniProtKB:P08729}.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC       {ECO:0000250|UniProtKB:P08729}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P08729}.
CC   -!- DEVELOPMENTAL STAGE: Expressed first at gastrulation (stage 11) and is
CC       found to rapidly increase during neurulation and further development.
CC       In the adult, it is a major polypeptide in the esophageal mucosa.
CC       {ECO:0000269|PubMed:2478354}.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; X14427; CAA32587.1; -; mRNA.
DR   PIR; S08381; S08381.
DR   RefSeq; NP_001095227.1; NM_001101757.1.
DR   AlphaFoldDB; P16878; -.
DR   SMR; P16878; -.
DR   BioGRID; 99216; 1.
DR   PRIDE; P16878; -.
DR   GeneID; 397878; -.
DR   KEGG; xla:397878; -.
DR   CTD; 397878; -.
DR   Xenbase; XB-GENE-876884; krt7.L.
DR   OrthoDB; 824246at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 397878; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Intermediate filament; Keratin; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..513
FT                   /note="Keratin, type II cytoskeletal 7"
FT                   /id="PRO_0000063720"
FT   DOMAIN          128..440
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          2..127
FT                   /note="Head"
FT   REGION          21..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..163
FT                   /note="Coil 1A"
FT   REGION          164..181
FT                   /note="Linker 1"
FT   REGION          182..273
FT                   /note="Coil 1B"
FT   REGION          274..297
FT                   /note="Linker 12"
FT   REGION          298..436
FT                   /note="Coil 2"
FT   REGION          437..513
FT                   /note="Tail"
FT   REGION          439..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..467
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  55451 MW;  8FC32D13C9511516 CRC64;
     MAFNSRQSSF STRSAVPNAG FSQMRISSTR SSSGGSGLGR EGGNFSSSSL SNLGSVKRSV
     SYGVSSGRSG GAGFGGAGFG GAGYGGSGFG GGVAYSGPGI QEVTINQSLL SPLNLEIDPT
     IQTVRQEERE QIKTLNNKFA SFIDKVRFLE QQNRVLETKW ELLQNQKSAK ASNIGPLFEA
     YIANLRRQLE SLTNDKGKLE GELRNMQDLV EDFKNKYEDE INKRTGAENE FVVLKKDVDA
     AYMNKVELES KMEGLTDEIN FLRALYEAEL RELQEQISDT SVVLSMDNNR ALDMDSIIAE
     VKAQYEDIAN KSRANAESAY QSKFQELQAA AGRHGDDLRS TKTEISELNR AMQRLQAEIE
     SVKAQRAKLE AQIAEAEERG ELALKDARSK LAELEAALQK AKQDMARQLR EYQELMNVKL
     ALDIEIATYR KLLEGEENRI TEGPGPVSVS VVNSTSSSMG GGSSSGFGSG YSGGSSYGAG
     GFGNSSARFG SGGSSGVKSY SVTTTSSSRS FRQ