ID   K2C80_BOVIN             Reviewed;         422 AA.
AC   A0JND2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Keratin, type II cytoskeletal 80;
DE   AltName: Full=Cytokeratin-80;
DE            Short=CK-80;
DE   AltName: Full=Keratin-80;
DE            Short=K80;
DE   AltName: Full=Type-II keratin Kb20;
GN   Name=KRT80;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC       respectively).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC126624; AAI26625.1; -; mRNA.
DR   EMBL; BC147909; AAI47910.1; -; mRNA.
DR   RefSeq; NP_001071420.1; NM_001077952.1.
DR   AlphaFoldDB; A0JND2; -.
DR   SMR; A0JND2; -.
DR   STRING; 9913.ENSBTAP00000007288; -.
DR   PaxDb; A0JND2; -.
DR   PRIDE; A0JND2; -.
DR   Ensembl; ENSBTAT00000007288; ENSBTAP00000007288; ENSBTAG00000007204.
DR   GeneID; 522400; -.
DR   KEGG; bta:522400; -.
DR   CTD; 144501; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007204; -.
DR   VGNC; VGNC:30742; KRT80.
DR   eggNOG; ENOG502RVYD; Eukaryota.
DR   GeneTree; ENSGT00940000161279; -.
DR   HOGENOM; CLU_012560_5_4_1; -.
DR   InParanoid; A0JND2; -.
DR   OrthoDB; 669704at2759; -.
DR   TreeFam; TF317854; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000007204; Expressed in zone of skin and 89 other tissues.
DR   ExpressionAtlas; A0JND2; baseline.
DR   GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..422
FT                   /note="Keratin, type II cytoskeletal 80"
FT                   /id="PRO_0000314895"
FT   DOMAIN          83..394
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..82
FT                   /note="Head"
FT   REGION          83..118
FT                   /note="Coil 1A"
FT   REGION          119..135
FT                   /note="Linker 1"
FT   REGION          136..227
FT                   /note="Coil 1B"
FT   REGION          228..251
FT                   /note="Linker 12"
FT   REGION          252..390
FT                   /note="Coil 2"
FT   REGION          391..422
FT                   /note="Tail"
FT   SITE            334
FT                   /note="Stutter"
FT   MOD_RES         45
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6KB66"
SQ   SEQUENCE   422 AA;  47438 MW;  180AF4D400CB8E03 CRC64;
     MACRSCVVGF SSLSSCEVTP AGSPRPATAG WSSCGPPEPG LSSHSLTGCW TAGTVSKVTV
     NPSLLVPLDL KVDPAIQQQK NNEKEEMKVL NDKFASLIGK VQALEQRNQL LETRWHFLQS
     QDSATFDLGH LYEEYQGRLQ EELRKVSKER GQLEANLLQV LEKVEDFRIR YEDEISKRTD
     MEFTFVQLKK DLDAECLRRT ELETKLKGLQ SFVELMKSIY EQELKDLAAQ LKDVSVTVGM
     DSRCHIDLSG IVEEVKAQYD AVAARSLEEA EAYSRSQLEE RAACSAEFEN SLQSSRSEIA
     DLNVRIQKLR SQILSIKSHC LKLEENIKVA EEQGELAFQD AKAKLAQLED ALQQAKKDMA
     RQLREYQELM NTKLALDIEI ATYRKLMEGE ESRMDMPSAT VVSAVQARCR TAPTLPHPLC
     SL