ID   K2C80_MOUSE             Reviewed;         452 AA.
AC   Q0VBK2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Keratin, type II cytoskeletal 80;
DE   AltName: Full=Cytokeratin-80;
DE            Short=CK-80;
DE   AltName: Full=Keratin-80;
DE            Short=K80;
DE   AltName: Full=Type-II keratin Kb20;
GN   Name=Krt80; Synonyms=Kb20;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC       respectively).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; BC119366; AAI19367.1; -; mRNA.
DR   EMBL; BC120601; AAI20602.1; -; mRNA.
DR   CCDS; CCDS37216.1; -.
DR   RefSeq; NP_083046.2; NM_028770.2.
DR   AlphaFoldDB; Q0VBK2; -.
DR   SMR; Q0VBK2; -.
DR   BioGRID; 216512; 2.
DR   ComplexPortal; CPX-5866; Keratin-80- Keratin-82 dimer complex.
DR   IntAct; Q0VBK2; 1.
DR   MINT; Q0VBK2; -.
DR   STRING; 10090.ENSMUSP00000076437; -.
DR   iPTMnet; Q0VBK2; -.
DR   PhosphoSitePlus; Q0VBK2; -.
DR   PaxDb; Q0VBK2; -.
DR   PeptideAtlas; Q0VBK2; -.
DR   PRIDE; Q0VBK2; -.
DR   ProteomicsDB; 269147; -.
DR   Antibodypedia; 43038; 162 antibodies from 24 providers.
DR   DNASU; 74127; -.
DR   Ensembl; ENSMUST00000077196; ENSMUSP00000076437; ENSMUSG00000037185.
DR   GeneID; 74127; -.
DR   KEGG; mmu:74127; -.
DR   UCSC; uc007xta.1; mouse.
DR   CTD; 144501; -.
DR   MGI; MGI:1921377; Krt80.
DR   VEuPathDB; HostDB:ENSMUSG00000037185; -.
DR   eggNOG; ENOG502RVYD; Eukaryota.
DR   GeneTree; ENSGT00940000161279; -.
DR   HOGENOM; CLU_012560_5_4_1; -.
DR   InParanoid; Q0VBK2; -.
DR   OMA; HHYEEYQ; -.
DR   OrthoDB; 669704at2759; -.
DR   PhylomeDB; Q0VBK2; -.
DR   TreeFam; TF317854; -.
DR   Reactome; R-MMU-6805567; Keratinization.
DR   Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR   BioGRID-ORCS; 74127; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Krt80; mouse.
DR   PRO; PR:Q0VBK2; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q0VBK2; protein.
DR   Bgee; ENSMUSG00000037185; Expressed in lip and 99 other tissues.
DR   ExpressionAtlas; Q0VBK2; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005882; C:intermediate filament; ISO:MGI.
DR   GO; GO:0045111; C:intermediate filament cytoskeleton; ISO:MGI.
DR   GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Intermediate filament; Keratin; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..452
FT                   /note="Keratin, type II cytoskeletal 80"
FT                   /id="PRO_0000314897"
FT   DOMAIN          83..394
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..82
FT                   /note="Head"
FT   REGION          82..118
FT                   /note="Coil 1A"
FT   REGION          119..135
FT                   /note="Linker 1"
FT   REGION          136..227
FT                   /note="Coil 1B"
FT   REGION          228..251
FT                   /note="Linker 12"
FT   REGION          252..390
FT                   /note="Coil 2"
FT   REGION          391..452
FT                   /note="Tail"
FT   REGION          412..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            334
FT                   /note="Stutter"
FT   MOD_RES         45
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6KB66"
SQ   SEQUENCE   452 AA;  50660 MW;  C40B0C724A43720C CRC64;
     MAYRSCVVGF SSLSGCEMTP AGSPQPGTSG WGSCGLPGPG FSSRSLTSCR PAGTIPKVTV
     NPSLLVPLDL KVDPAVQQQK NQEKEEMKAL NDKFASLIGK VQALEQRNQL LETRWSFLQG
     QGSATFDLSH HYETFQGRLQ EELRKVSQER GQLEANLLQV LEKVEEFRVR YEDEISKRTD
     LEFTFVQLKK DLDAECLRRT ELETKLKGLQ GFLELMRTVY EQELKDLTAQ VKDVSVTVGL
     DSRCHIDLSG IVEEVKAQYD AIAARSLEEA EAYSRSQLEE RAARSAEFGN SLQSSRCEIA
     DLNVRIQKLR SQIVSVKSHC LKLEENIKVA EEQGELAFQD AKDKMAQLEN ALQKAKQDMA
     RQLREYQDLM NTKLALDIEI ATYHKLMEGE ESRMDLPSAT VVSTVKSGCR TTASKSGLTK
     TSSRKKKNRR GPVIKITEMS EKYLSQESEA SE