K2C80_RAT
ID K2C80_RAT Reviewed; 452 AA.
AC Q6IMF1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Keratin, type II cytoskeletal 80;
DE AltName: Full=Cytokeratin-80;
DE Short=CK-80;
DE AltName: Full=Keratin-80;
DE Short=K80;
DE AltName: Full=Type-II keratin Kb20;
GN Name=Krt80; Synonyms=Kb20;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=15085952; DOI=10.1078/0171-9335-00354;
RA Hesse M., Zimek A., Weber K., Magin T.M.;
RT "Comprehensive analysis of keratin gene clusters in humans and rodents.";
RL Eur. J. Cell Biol. 83:19-26(2004).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa,
CC respectively).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AABR03055900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03056151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001581; DAA02056.1; -; mRNA.
DR EMBL; BK001582; DAA02057.1; -; mRNA.
DR RefSeq; NP_001008815.1; NM_001008815.1.
DR AlphaFoldDB; Q6IMF1; -.
DR SMR; Q6IMF1; -.
DR STRING; 10116.ENSRNOP00000038848; -.
DR iPTMnet; Q6IMF1; -.
DR PhosphoSitePlus; Q6IMF1; -.
DR PaxDb; Q6IMF1; -.
DR PRIDE; Q6IMF1; -.
DR GeneID; 315318; -.
DR KEGG; rno:315318; -.
DR UCSC; RGD:1359177; rat.
DR CTD; 144501; -.
DR RGD; 1359177; Krt80.
DR VEuPathDB; HostDB:ENSRNOG00000025994; -.
DR eggNOG; ENOG502RVYD; Eukaryota.
DR HOGENOM; CLU_012560_5_4_1; -.
DR InParanoid; Q6IMF1; -.
DR OMA; HHYEEYQ; -.
DR OrthoDB; 669704at2759; -.
DR PhylomeDB; Q6IMF1; -.
DR TreeFam; TF317854; -.
DR Reactome; R-RNO-6805567; Keratinization.
DR Reactome; R-RNO-6809371; Formation of the cornified envelope.
DR PRO; PR:Q6IMF1; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000025994; Expressed in esophagus and 15 other tissues.
DR Genevisible; Q6IMF1; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Intermediate filament; Keratin; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..452
FT /note="Keratin, type II cytoskeletal 80"
FT /id="PRO_0000314898"
FT DOMAIN 83..394
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..82
FT /note="Head"
FT REGION 82..118
FT /note="Coil 1A"
FT REGION 119..135
FT /note="Linker 1"
FT REGION 136..227
FT /note="Coil 1B"
FT REGION 228..251
FT /note="Linker 12"
FT REGION 252..390
FT /note="Coil 2"
FT REGION 391..452
FT /note="Tail"
FT REGION 411..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 334
FT /note="Stutter"
FT MOD_RES 45
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6KB66"
SQ SEQUENCE 452 AA; 50550 MW; FEDBE9145CA03721 CRC64;
MAYRSCVVGF SSHSGCEVTP AGSSQPGTSG WGSCGLPGPG FSSRSLTSCR PAGVIPKVTV
NPSLLVPLDL KVDPAVQQQK NQEKEEMKVL NDKFASLIGK VQALEQRNQL LETRWGFLQG
QGSATFDLSH HYETFQGRLQ EELRKVSQER GQLEASLLQV LEKVEEFRVR YEDEISKRTD
LEFTFVQLKK DLDAECLRRT ELETKLKGLQ GFVELMRTVY EQELKDLTAQ VKDVSVTVGL
DSRCHIDLSG IVEEVKAQYD AIAARSLEEA EAYSRSQLEE RAARSAEFGN SLQSSRCEIA
DLNVRIQKLR SQIVSVKSHC LKLEENIKVA EEQGELAFQD AKDKMAQLEA ALQKAKQDMA
RQLREYQDLM NTKLALDIEI ATYHKLMEGE ESRMDLPSTT VVSAVQSRCR TTASKSGLSK
TPSRKKKNRG GPVIKITEMS EKYLSQESEA SE
