K2CO_CHICK
ID K2CO_CHICK Reviewed; 492 AA.
AC O93532;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Keratin, type II cytoskeletal cochleal;
DE AltName: Full=Cytokeratin otokeratin;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000312|EMBL:AAC64042.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=White leghorn; TISSUE=Basilar papilla;
RX PubMed=9736748; DOI=10.1073/pnas.95.19.11400;
RA Heller S., Sheane C.A., Javed Z., Hudspeth A.J.;
RT "Molecular markers for cell types of the inner ear and candidate genes for
RT hearing disorders.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:11400-11405(1998).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC {ECO:0000250|UniProtKB:P16878}.
CC -!- TISSUE SPECIFICITY: Abundant in the cochlea of the inner ear, where it
CC is found in the cells of the tegmentum vasculosum. Lower levels also
CC found in the heart and forebrain. {ECO:0000269|PubMed:9736748}.
CC -!- DEVELOPMENTAL STAGE: Specifically expressed at the late developmental
CC stages in the cochlea. {ECO:0000269|PubMed:9736748}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AF072698; AAC64042.1; -; mRNA.
DR PIR; A60093; A60093.
DR RefSeq; NP_990263.1; NM_204932.1.
DR AlphaFoldDB; O93532; -.
DR SMR; O93532; -.
DR STRING; 9031.ENSGALP00000016651; -.
DR PRIDE; O93532; -.
DR GeneID; 395772; -.
DR KEGG; gga:395772; -.
DR CTD; 3855; -.
DR VEuPathDB; HostDB:geneid_395772; -.
DR eggNOG; ENOG502QURK; Eukaryota.
DR OrthoDB; 824246at2759; -.
DR PhylomeDB; O93532; -.
DR PRO; PR:O93532; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0045095; C:keratin filament; IBA:GO_Central.
DR GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0031424; P:keratinization; IBA:GO_Central.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT CHAIN 1..492
FT /note="Keratin, type II cytoskeletal cochleal"
FT /id="PRO_0000063746"
FT DOMAIN 114..425
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..113
FT /note="Head"
FT REGION 114..149
FT /note="Coil 1A"
FT REGION 150..166
FT /note="Linker 1"
FT REGION 167..259
FT /note="Coil 1B"
FT REGION 260..282
FT /note="Linker 12"
FT REGION 283..421
FT /note="Coil 2"
FT REGION 422..492
FT /note="Tail"
SQ SEQUENCE 492 AA; 53803 MW; A01A66426B9F3941 CRC64;
MSRSVSFSSR SVAVPGVSQV RVSSVSSVRG GGSLNKAGGF GSSSLYNLGS ANKRISLGGS
SSYSVRSGYG YGGMGFGGAI APSAGIQEVT VNQNLLTPLN LEIDPNIQRV RKEEKEQIKT
LNNRFASFID KVRFLEQQNK MLETKWSLLQ DQKTTRSNIV PMFEAYITNL RRQLDGLLND
KGRLEGELRN MQDLVEDFKA KYEDEINKRT TAENEFVVLK KDVDAAYMNK VELEAKVDAL
TDEINFLRSL YEAELRELQA QISDTSVVLS MDNSRNLDLD SIIAEVKAQY EDIANRSRAE
AESWYQSKFE ALQVTAGKHG DDLRNTKNEI TEINRVIQRL QGEIENAKAQ RAKMEAAIAE
AEERGELAVK DARAKLEELE AALQKAKQDM ARQLREYQEL MNVKLALDIE IATYRKLLEG
EESRLAGDGV GSVNISMVSS SGGGSSGFLG GGVRGGLALG AGMGSGALGF SSGGSTKSYT
VTTTSSTRSF RK
