ID   K2M1_SHEEP              Reviewed;         109 AA.
AC   P02539;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Keratin, type II microfibrillar;
DE   AltName: Full=Low-sulfur keratin;
DE   Flags: Fragment;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=581264; DOI=10.1042/bj1730365;
RA   Crewther W.G., Inglis A.S., McKern N.M.;
RT   "Amino acid sequences of alpha-helical segments from S-
RT   carboxymethylkerateine-A. Complete sequence of a type-II segment.";
RL   Biochem. J. 173:365-371(1978).
CC   -!- FUNCTION: Wool microfibrillar keratin.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   AlphaFoldDB; P02539; -.
DR   SMR; P02539; -.
DR   STRING; 9940.ENSOARP00000018386; -.
DR   PRIDE; P02539; -.
DR   eggNOG; ENOG502RTZU; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Intermediate filament; Keratin;
KW   Reference proteome.
FT   CHAIN           <1..>109
FT                   /note="Keratin, type II microfibrillar"
FT                   /id="PRO_0000063747"
FT   DOMAIN          <1..>109
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..10
FT                   /note="Linker 1"
FT   REGION          11..>109
FT                   /note="Coil 1B"
FT   VARIANT         51
FT                   /note="R -> K"
FT   VARIANT         52
FT                   /note="R -> K"
FT   NON_TER         1
FT   NON_TER         109
SQ   SEQUENCE   109 AA;  12683 MW;  679DDDAA5A621CF8 CRC64;
     QNRQCCESNL EPLFSGYIET LRREAECAEA DSGRLSSELN SLQEVLEGYK RRYEEEVALR
     ATAENEFVAL KKDVDCAYLR KSDLEANVEA LIQETDFLRR LYEEEIRVL