ID   K2M2_SHEEP              Reviewed;         491 AA.
AC   P15241;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Keratin, type II microfibrillar, component 7C;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2803231; DOI=10.1042/bj2611015;
RA   Sparrow L.G., Robinson C.P., McMahon D.T.W., Rubira M.R.;
RT   "The amino acid sequence of component 7c, a type II intermediate-filament
RT   protein from wool.";
RL   Biochem. J. 261:1015-1022(1989).
CC   -!- FUNCTION: Wool microfibrillar keratin.
CC   -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC       keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC   -!- MISCELLANEOUS: The low-sulfur proteins, derived from the microfibrillar
CC       fraction of wool extracts, are composed of two families, each
CC       consisting of 4 homologous subunits: the type I components (8C-1, 8C-2,
CC       8A and 8B) and the type II components (5, 7A, 7B, and 7C).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   PIR; S05408; S05408.
DR   AlphaFoldDB; P15241; -.
DR   SMR; P15241; -.
DR   PRIDE; P15241; -.
DR   eggNOG; ENOG502SKJW; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Intermediate filament; Keratin;
KW   Reference proteome.
FT   CHAIN           1..491
FT                   /note="Keratin, type II microfibrillar, component 7C"
FT                   /id="PRO_0000063748"
FT   DOMAIN          109..420
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..109
FT                   /note="Head"
FT   REGION          110..144
FT                   /note="Coil 1A"
FT   REGION          145..154
FT                   /note="Linker 1"
FT   REGION          155..255
FT                   /note="Coil 1B"
FT   REGION          256..272
FT                   /note="Linker 12"
FT   REGION          273..416
FT                   /note="Coil 2"
FT   REGION          417..491
FT                   /note="Tail"
FT   MOD_RES         1
FT                   /note="Blocked amino end (Cys)"
FT   VARIANT         74
FT                   /note="C -> G"
FT   VARIANT         74
FT                   /note="C -> S"
FT   VARIANT         80
FT                   /note="C -> S"
FT   VARIANT         144
FT                   /note="F -> Y"
FT   VARIANT         232
FT                   /note="S -> V"
FT   VARIANT         276
FT                   /note="C -> D"
FT   VARIANT         276
FT                   /note="C -> N"
FT   VARIANT         284
FT                   /note="Q -> H"
FT   UNSURE          1..2
FT                   /note="CG or GC"
SQ   SEQUENCE   491 AA;  53682 MW;  A801771FE3831ABE CRC64;
     CGFSTVGSGF GSRAFSCVSA CGPRPGRCCI TAAPYRGISC YRGLTGGFGS RSVCGGFRAG
     SCGRSFGYRS GGVCGPSPPC ITTVSVNESL LTPLNLEIDP NAQCVKQEEK EQIKCLNNRF
     AAFIDKVRFL EQQNKLLETK LQFFQNRQCC ESNLEPLFEG YIETLRREAE CVEADSGRLS
     SELNHVQEVL EGYKKKYEQE VALRATAENE FVALKKDVDC AYVRKSDLEA NSEALIQEID
     FLRRLYQEEI RVLQANISDT SVIVKMDNSR DLNMDCIVAE IKAQYDDIAS RSRAEAESWY
     RSKCEEIKAT VIRHGETLRR TKEEINELNR VIQRLTAEVE NAKCQNSKLE AAVTQAEQQG
     EVALNDARCK LAGLEEALQK AKQDMACLLK EYQEVMNSKL GLDIEIATYR RLLEGEEQRL
     CEGVGAVNVC VSSSRGGVVC GDLCVSGSRP VTGSVCSAPC SGNLAVSTGL CAPCGQLNTT
     CGGGSCSLGR C