ID   K3_SWPVK                Reviewed;          86 AA.
AC   P32224;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protein K3 homolog;
GN   ORFNames=C8L;
OS   Swinepox virus (strain Kasza) (SWPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Suipoxvirus.
OX   NCBI_TaxID=10277;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8249275; DOI=10.1006/viro.1993.1625;
RA   Massung R.F., Jayarama V., Moyer R.W.;
RT   "DNA sequence analysis of conserved and unique regions of swinepox virus:
RT   identification of genetic elements supporting phenotypic observations
RT   including a novel G protein-coupled receptor homologue.";
RL   Virology 197:511-528(1993).
CC   -!- FUNCTION: Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for
CC       EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by
CC       host EIF2AK2/PKR kinase and prevents protein synthesis shutoff (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host PKR kinase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae K3 protein family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L22013; AAC37863.1; -; Genomic_DNA.
DR   RefSeq; NP_570170.1; NC_003389.1.
DR   SMR; P32224; -.
DR   GeneID; 932392; -.
DR   KEGG; vg:932392; -.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039580; P:suppression by virus of host PKR signaling; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR016397; Serpin_prd_poxvir.
DR   PIRSF; PIRSF003760; VAC_K3L_Serpin_prd; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host PKR by virus; RNA-binding; Viral immunoevasion.
FT   CHAIN           1..86
FT                   /note="Protein K3 homolog"
FT                   /id="PRO_0000099600"
FT   DOMAIN          15..86
FT                   /note="S1 motif"
SQ   SEQUENCE   86 AA;  9787 MW;  5F9CFC45A38E9231 CRC64;
     MSTMNTLAFC YGLPNINDIT QGIIFVRNNI FYSYLTDYAM EACILNYINI RADKIEDLKK
     SLVGKTISVR VIRVDVLKGY IDVSIV