ID   K4_VACCC                Reviewed;         424 AA.
AC   P20537;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Phospholipase-D-like protein K4;
GN   ORFNames=K4L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: DNA nicking enzyme that cleaves extruded cruciform DNA at its
CC       apex (By similarity). Probably nicks viral hairpins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Virion core.
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M35027; AAA48010.1; -; Genomic_DNA.
DR   PIR; C42505; WMVZCX.
DR   SMR; P20537; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   InterPro; IPR032803; PLDc_3.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF00614; PLDc; 2.
DR   Pfam; PF13918; PLDc_3; 1.
DR   SMART; SM00155; PLDc; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; Repeat; Virion.
FT   CHAIN           1..424
FT                   /note="Phospholipase-D-like protein K4"
FT                   /id="PRO_0000099601"
FT   DOMAIN          110..137
FT                   /note="PLD phosphodiesterase 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
FT   DOMAIN          320..346
FT                   /note="PLD phosphodiesterase 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"
SQ   SEQUENCE   424 AA;  48877 MW;  E7A59E450B9C4F3A CRC64;
     MNPDNTIAVI TETIPIGMQF DKVYLSTFNM WREILSNTTK TLDISSFYWS LSDEVGTNFG
     TIILNEIVQL PKRGVRVRVA VNKSNKPLKD VERLQMAGVE VRYIDITNIL GGVLHTKFWI
     SDNTHIYLGS ANMDWRSLTQ VKELGIAIFN NRNLAADLTQ IFEVYWYLGV NNLPYNWKNF
     YPSYYNTDHP LSINVSGVPH SVFIASAPQQ LCTMERTNDL TALLSCIRNA SKFVYVSVMN
     FIPIIYSKAG KILFWPYIED ELRRSAIDRQ VSVKLLISCW QRSSFIMRNF LRSIAMLKSK
     NIDIEVKLFI VPDADPPIPY SRVNHAKYMV TDKTAYIGTS NWTGNYFTDT CGASINITPD
     DGLGLRQQLE DIFMRDWNSK YSYELYDTSP TKRCKLLKNM KQCTNDIYCD EIQPEKEIPE
     YSLE