ID   K7_HHV8P                Reviewed;         126 AA.
AC   F5HDA4;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 25.
DE   RecName: Full=Protein K7;
GN   Name=K7;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION, INTERACTION WITH HOST CAMLG, AND SUBCELLULAR LOCATION.
RX   PubMed=12388711; DOI=10.1128/jvi.76.22.11491-11504.2002;
RA   Feng P., Park J., Lee B.S., Lee S.H., Bram R.J., Jung J.U.;
RT   "Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a
RT   cellular calcium-modulating cyclophilin ligand to modulate intracellular
RT   calcium concentration and inhibit apoptosis.";
RL   J. Virol. 76:11491-11504(2002).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH PROTEIN ORF74.
RX   PubMed=18802460; DOI=10.1371/journal.ppat.1000157;
RA   Feng H., Dong X., Negaard A., Feng P.;
RT   "Kaposi's sarcoma-associated herpesvirus K7 induces viral G protein-coupled
RT   receptor degradation and reduces its tumorigenicity.";
RL   PLoS Pathog. 4:E1000157-E1000157(2008).
CC   -!- FUNCTION: Plays a role in the inhibition of host apoptosis to allow
CC       completion of the viral lytic replication and may thus favor the
CC       maintenance of persistent infection in infected host.
CC       {ECO:0000269|PubMed:12388711, ECO:0000269|PubMed:18802460}.
CC   -!- SUBUNIT: Interacts with host CAMLG; this interaction allows efficient
CC       apoptosis inhibition. Additionally, interacts with vGPCR/ORF74 and
CC       induces its proteasomeal degradation. {ECO:0000269|PubMed:12388711,
CC       ECO:0000269|PubMed:18802460}.
CC   -!- INTERACTION:
CC       F5HDA4; Q98146: ORF74; NbExp=5; IntAct=EBI-9002986, EBI-7930093;
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Host mitochondrion
CC       {ECO:0000269|PubMed:12388711}.
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DR   EMBL; AF148805; ABD28865.1; -; Genomic_DNA.
DR   RefSeq; YP_001129367.1; NC_009333.1.
DR   IntAct; F5HDA4; 1.
DR   PRIDE; F5HDA4; -.
DR   DNASU; 4961500; -.
DR   GeneID; 4961500; -.
DR   KEGG; vg:4961500; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host membrane; Host mitochondrion; Host-virus interaction; Membrane;
KW   Modulation of host cell apoptosis by virus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..126
FT                   /note="Protein K7"
FT                   /id="PRO_0000423844"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   126 AA;  13743 MW;  189A7D9FCEDD91E3 CRC64;
     MGTLEIKGAS LSQFSTGTAQ SPWLPLHLWI LCSLLAFLPL LVFIGAADCG LIASLLAIYP
     SWLSARFSVL LFPHWPESCS TKNTARSGAL HKPAEQKLRF AQKPCHGNYT VTPCGLLHWI
     QSPGQL