ID   K7_VACCA                Reviewed;         149 AA.
AC   Q76ZX2;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   29-SEP-2021, entry version 54.
DE   RecName: Full=Protein K7;
GN   OrderedLocusNames=MVA028R, ACAM3000_MVA_028;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bcl-2-like protein which, through its interaction with the
CC       DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated
CC       IRF3 activation. Contributes to virulence by binding to the host TRAF6
CC       and IRAK2 and preventing host NF-kappa-B activation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DDDX3; this interaction inhibits DDX3 and
CC       suppresses DDX3-mediated IFN-beta promoter induction. Interacts with
CC       TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB
CC       activation (By similarity). {ECO:0000250}.
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DR   EMBL; U94848; AAB96484.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10426.1; -; Genomic_DNA.
DR   RefSeq; YP_232921.1; NC_006998.1.
DR   BMRB; Q76ZX2; -.
DR   SMR; Q76ZX2; -.
DR   DNASU; 3707496; -.
DR   GeneID; 3707496; -.
DR   KEGG; vg:3707496; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.20; -; 1.
DR   InterPro; IPR009174; Orthopox_K7.
DR   InterPro; IPR022819; Poxvirus_Bcl-2-like.
DR   InterPro; IPR043018; Poxvirus_sf.
DR   Pfam; PF06227; Poxvirus; 1.
DR   PIRSF; PIRSF003764; VAC_K7R; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host RLR pathway by virus; Viral immunoevasion.
FT   CHAIN           1..149
FT                   /note="Protein K7"
FT                   /id="PRO_0000099607"
SQ   SEQUENCE   149 AA;  17468 MW;  B3E972A93DF97DC8 CRC64;
     MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC GRLYKELMKF
     DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA TIGICAKITE HWGYKKISES
     RFQSLGNITD LMTDDNINIL ILFLEKKLN