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K7_VACCC
ID   K7_VACCC                Reviewed;         149 AA.
AC   P68467; P18382;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   29-SEP-2021, entry version 57.
DE   RecName: Full=Protein K7;
GN   ORFNames=K7R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Bcl-2-like protein which, through its interaction with the
CC       DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated
CC       IRF3 activation. Contributes to virulence by binding to the host TRAF6
CC       and IRAK2 and preventing host NF-kappa-B activation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DDDX3; this interaction inhibits DDX3 and
CC       suppresses DDX3-mediated IFN-beta promoter induction. Interacts with
CC       TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB
CC       activation (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P68467; O00571: DDX3X; Xeno; NbExp=6; IntAct=EBI-8022707, EBI-353779;
CC       P68467; O43187: IRAK2; Xeno; NbExp=2; IntAct=EBI-8022707, EBI-447733;
CC   -!- SIMILARITY: Belongs to the poxviridae K7 protein family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48013.1; -; Genomic_DNA.
DR   PIR; JS0217; WMVZK7.
DR   BMRB; P68467; -.
DR   SMR; P68467; -.
DR   IntAct; P68467; 3.
DR   MINT; P68467; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.20; -; 1.
DR   InterPro; IPR009174; Orthopox_K7.
DR   InterPro; IPR022819; Poxvirus_Bcl-2-like.
DR   InterPro; IPR043018; Poxvirus_sf.
DR   Pfam; PF06227; Poxvirus; 1.
DR   PIRSF; PIRSF003764; VAC_K7R; 1.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host RLR pathway by virus; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..149
FT                   /note="Protein K7"
FT                   /id="PRO_0000099608"
SQ   SEQUENCE   149 AA;  17468 MW;  B3E972A93DF97DC8 CRC64;
     MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC GRLYKELMKF
     DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA TIGICAKITE HWGYKKISES
     RFQSLGNITD LMTDDNINIL ILFLEKKLN
 
 
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