K7_VACCC
ID K7_VACCC Reviewed; 149 AA.
AC P68467; P18382;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 29-SEP-2021, entry version 57.
DE RecName: Full=Protein K7;
GN ORFNames=K7R;
OS Vaccinia virus (strain Copenhagen) (VACV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=10249;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA Paoletti E.;
RT "The complete DNA sequence of vaccinia virus.";
RL Virology 179:247-266(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA Paoletti E.;
RT "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL Virology 179:517-563(1990).
CC -!- FUNCTION: Bcl-2-like protein which, through its interaction with the
CC DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated
CC IRF3 activation. Contributes to virulence by binding to the host TRAF6
CC and IRAK2 and preventing host NF-kappa-B activation (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with DDDX3; this interaction inhibits DDX3 and
CC suppresses DDX3-mediated IFN-beta promoter induction. Interacts with
CC TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB
CC activation (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC P68467; O00571: DDX3X; Xeno; NbExp=6; IntAct=EBI-8022707, EBI-353779;
CC P68467; O43187: IRAK2; Xeno; NbExp=2; IntAct=EBI-8022707, EBI-447733;
CC -!- SIMILARITY: Belongs to the poxviridae K7 protein family. {ECO:0000305}.
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DR EMBL; M35027; AAA48013.1; -; Genomic_DNA.
DR PIR; JS0217; WMVZK7.
DR BMRB; P68467; -.
DR SMR; P68467; -.
DR IntAct; P68467; 3.
DR MINT; P68467; -.
DR Proteomes; UP000008269; Genome.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.437.20; -; 1.
DR InterPro; IPR009174; Orthopox_K7.
DR InterPro; IPR022819; Poxvirus_Bcl-2-like.
DR InterPro; IPR043018; Poxvirus_sf.
DR Pfam; PF06227; Poxvirus; 1.
DR PIRSF; PIRSF003764; VAC_K7R; 1.
PE 1: Evidence at protein level;
KW Host-virus interaction; Inhibition of host innate immune response by virus;
KW Inhibition of host RLR pathway by virus; Reference proteome;
KW Viral immunoevasion.
FT CHAIN 1..149
FT /note="Protein K7"
FT /id="PRO_0000099608"
SQ SEQUENCE 149 AA; 17468 MW; B3E972A93DF97DC8 CRC64;
MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC GRLYKELMKF
DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA TIGICAKITE HWGYKKISES
RFQSLGNITD LMTDDNINIL ILFLEKKLN