K7_VACCW
ID K7_VACCW Reviewed; 149 AA.
AC P68466; P18382;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 23-FEB-2022, entry version 69.
DE RecName: Full=Protein K7;
GN OrderedLocusNames=VACWR039; ORFNames=K7R;
OS Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS WR)).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=10254;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3264331; DOI=10.1099/0022-1317-69-12-2995;
RA Boursnell M.E.G., Foulds I.J., Campbell J.I., Binns M.M.;
RT "Non-essential genes in the vaccinia virus HindIII K fragment: a gene
RT related to serine protease inhibitors and a gene related to the 37K
RT vaccinia virus major envelope antigen.";
RL J. Gen. Virol. 69:2995-3003(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA Wohlhueter R.;
RT "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT redundancy and an error rate of 0.16/10kb.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION WITH HUMAN TRAF6 AND IRAK2.
RX PubMed=18636090; DOI=10.1038/emboj.2008.143;
RA Schroder M., Baran M., Bowie A.G.;
RT "Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-
RT mediated IRF activation.";
RL EMBO J. 27:2147-2157(2008).
RN [4]
RP INTERACTION WITH HUMAN DDX3X, AND X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
RX PubMed=19913487; DOI=10.1016/j.str.2009.09.005;
RA Oda S., Schroder M., Khan A.R.;
RT "Structural basis for targeting of human RNA helicase DDX3 by poxvirus
RT protein K7.";
RL Structure 17:1528-1537(2009).
CC -!- FUNCTION: Bcl-2-like protein which, through its interaction with the
CC DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated
CC IRF3 activation. Contributes to virulence by binding to the host TRAF6
CC and IRAK2 and preventing host NF-kappa-B activation.
CC -!- SUBUNIT: Interacts with DDDX3; this interaction inhibits DDX3 and
CC suppresses DDX3-mediated IFN-beta promoter induction. Interacts with
CC TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB
CC activation. {ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:19913487}.
CC -!- INTERACTION:
CC P68466; O00571: DDX3X; Xeno; NbExp=6; IntAct=EBI-6152154, EBI-353779;
CC -!- SIMILARITY: Belongs to the poxviridae K7 protein family. {ECO:0000305}.
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DR EMBL; D00382; BAA00293.1; -; Genomic_DNA.
DR EMBL; AY243312; AAO89318.1; -; Genomic_DNA.
DR PIR; JS0217; WMVZK7.
DR RefSeq; YP_232921.1; NC_006998.1.
DR PDB; 2K36; NMR; -; A=1-149.
DR PDB; 3JRV; X-ray; 1.60 A; A/B=1-149.
DR PDBsum; 2K36; -.
DR PDBsum; 3JRV; -.
DR BMRB; P68466; -.
DR SMR; P68466; -.
DR DIP; DIP-48288N; -.
DR IntAct; P68466; 28.
DR DNASU; 3707496; -.
DR GeneID; 3707496; -.
DR KEGG; vg:3707496; -.
DR EvolutionaryTrace; P68466; -.
DR Proteomes; UP000000344; Genome.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR DisProt; DP02194; -.
DR Gene3D; 1.10.437.20; -; 1.
DR IDEAL; IID90010; -.
DR InterPro; IPR009174; Orthopox_K7.
DR InterPro; IPR022819; Poxvirus_Bcl-2-like.
DR InterPro; IPR043018; Poxvirus_sf.
DR Pfam; PF06227; Poxvirus; 1.
DR PIRSF; PIRSF003764; VAC_K7R; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Host-virus interaction;
KW Inhibition of host innate immune response by virus;
KW Inhibition of host NF-kappa-B by virus;
KW Inhibition of host RLR pathway by virus; Reference proteome;
KW Viral immunoevasion.
FT CHAIN 1..149
FT /note="Protein K7"
FT /id="PRO_0000099609"
FT HELIX 7..9
FT /evidence="ECO:0007829|PDB:3JRV"
FT TURN 13..16
FT /evidence="ECO:0007829|PDB:3JRV"
FT HELIX 23..25
FT /evidence="ECO:0007829|PDB:3JRV"
FT HELIX 26..42
FT /evidence="ECO:0007829|PDB:3JRV"
FT STRAND 47..50
FT /evidence="ECO:0007829|PDB:2K36"
FT HELIX 52..58
FT /evidence="ECO:0007829|PDB:3JRV"
FT HELIX 60..68
FT /evidence="ECO:0007829|PDB:3JRV"
FT HELIX 70..80
FT /evidence="ECO:0007829|PDB:3JRV"
FT HELIX 89..91
FT /evidence="ECO:0007829|PDB:3JRV"
FT HELIX 95..114
FT /evidence="ECO:0007829|PDB:3JRV"
FT HELIX 119..121
FT /evidence="ECO:0007829|PDB:3JRV"
FT HELIX 128..131
FT /evidence="ECO:0007829|PDB:3JRV"
FT HELIX 134..148
FT /evidence="ECO:0007829|PDB:3JRV"
SQ SEQUENCE 149 AA; 17468 MW; B3E972A93DF97DC8 CRC64;
MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC GRLYKELMKF
DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA TIGICAKITE HWGYKKISES
RFQSLGNITD LMTDDNINIL ILFLEKKLN
