K895L_HUMAN
ID K895L_HUMAN Reviewed; 471 AA.
AC Q68EN5; A2VCS8; Q8N3H9; Q8NAQ5; Q96IE5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Uncharacterized protein KIAA0895-like;
GN Name=KIAA0895L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q68EN5; Q8NAP8: ZBTB8B; NbExp=3; IntAct=EBI-17494528, EBI-17494306;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q68EN5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q68EN5-2; Sequence=VSP_031690, VSP_031691;
CC Name=3;
CC IsoId=Q68EN5-3; Sequence=VSP_031689;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI28540.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAD38862.1; Type=Erroneous translation; Note=Erroneous translation incorporating non-existent frameshift.; Evidence={ECO:0000305};
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DR EMBL; AK092303; BAC03856.1; -; mRNA.
DR EMBL; AL834156; CAD38862.1; ALT_SEQ; mRNA.
DR EMBL; CH471092; EAW83091.1; -; Genomic_DNA.
DR EMBL; BC007594; AAH07594.1; -; mRNA.
DR EMBL; BC080183; AAH80183.1; -; mRNA.
DR EMBL; BC128539; AAI28540.1; ALT_INIT; mRNA.
DR CCDS; CCDS42177.1; -. [Q68EN5-1]
DR RefSeq; NP_001035805.1; NM_001040715.1. [Q68EN5-1]
DR AlphaFoldDB; Q68EN5; -.
DR BioGRID; 575692; 3.
DR IntAct; Q68EN5; 1.
DR iPTMnet; Q68EN5; -.
DR PhosphoSitePlus; Q68EN5; -.
DR BioMuta; KIAA0895L; -.
DR DMDM; 74736337; -.
DR MassIVE; Q68EN5; -.
DR PaxDb; Q68EN5; -.
DR PeptideAtlas; Q68EN5; -.
DR PRIDE; Q68EN5; -.
DR Antibodypedia; 68169; 20 antibodies from 8 providers.
DR DNASU; 653319; -.
DR Ensembl; ENST00000290881.11; ENSP00000290881.7; ENSG00000196123.13. [Q68EN5-1]
DR Ensembl; ENST00000561621.5; ENSP00000457099.1; ENSG00000196123.13. [Q68EN5-2]
DR Ensembl; ENST00000563902.2; ENSP00000456838.1; ENSG00000196123.13. [Q68EN5-1]
DR GeneID; 653319; -.
DR KEGG; hsa:653319; -.
DR MANE-Select; ENST00000563902.2; ENSP00000456838.1; NM_001040715.2; NP_001035805.1.
DR UCSC; uc002ert.4; human. [Q68EN5-1]
DR CTD; 653319; -.
DR DisGeNET; 653319; -.
DR GeneCards; KIAA0895L; -.
DR HGNC; HGNC:34408; KIAA0895L.
DR HPA; ENSG00000196123; Low tissue specificity.
DR neXtProt; NX_Q68EN5; -.
DR OpenTargets; ENSG00000196123; -.
DR PharmGKB; PA164721818; -.
DR VEuPathDB; HostDB:ENSG00000196123; -.
DR eggNOG; ENOG502QQGI; Eukaryota.
DR GeneTree; ENSGT00390000004417; -.
DR HOGENOM; CLU_038689_2_0_1; -.
DR InParanoid; Q68EN5; -.
DR OMA; WHSAEGR; -.
DR OrthoDB; 749754at2759; -.
DR PhylomeDB; Q68EN5; -.
DR TreeFam; TF329621; -.
DR PathwayCommons; Q68EN5; -.
DR SignaLink; Q68EN5; -.
DR BioGRID-ORCS; 653319; 28 hits in 1084 CRISPR screens.
DR ChiTaRS; KIAA0895L; human.
DR GeneWiki; KIAA0895L; -.
DR GenomeRNAi; 653319; -.
DR Pharos; Q68EN5; Tdark.
DR PRO; PR:Q68EN5; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q68EN5; protein.
DR Bgee; ENSG00000196123; Expressed in right hemisphere of cerebellum and 124 other tissues.
DR ExpressionAtlas; Q68EN5; baseline and differential.
DR Genevisible; Q68EN5; HS.
DR InterPro; IPR012548; DUF1704.
DR PANTHER; PTHR31817; PTHR31817; 1.
DR Pfam; PF08014; DUF1704; 1.
DR SMART; SM01154; DUF1704; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..471
FT /note="Uncharacterized protein KIAA0895-like"
FT /id="PRO_0000320619"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..282
FT /note="MVLDSGAQAYDQAPPSPPTSPPSLRHRLKPSDRDGPPLYPWSQSLALPLALA
FT VPPALQPQPEQQPFSQMLLGHRGHMRRSESTYSVNSTGRRGRGTLGRPPPGRGRNPGGG
FT TLRPAASLPHIAKTQRDAGHIASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQE
FT PMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKY
FT MQKEGCAGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEI -> MT
FT VQDDMGTQDVGQGGICILVPRRAGGNVSLGEFVHVCGCVGVGWGADGWERIHVCEPLWI
FT LGCESTGGGASRCLGLGEPVCEPEFRSMRMEVSRPEPRPDGTGPGLGSQAGPRTPRPAP
FT PPLAFPA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031689"
FT VAR_SEQ 385..408
FT /note="GCFSKDQVYLDGIVRILRHRQTID -> ARTRCTWTASCAFCDIARPSISRC
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_031690"
FT VAR_SEQ 409..471
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_031691"
SQ SEQUENCE 471 AA; 53446 MW; C60BC58B867DB156 CRC64;
MVLDSGAQAY DQAPPSPPTS PPSLRHRLKP SDRDGPPLYP WSQSLALPLA LAVPPALQPQ
PEQQPFSQML LGHRGHMRRS ESTYSVNSTG RRGRGTLGRP PPGRGRNPGG GTLRPAASLP
HIAKTQRDAG HIASKSPCML VALRPTNMDR ERDKFFQSHY TYNPQFEYQE PMPTAVLEKY
CEASGQFIHQ AVGIIEAVLE KFGTYEHFEA ATGGQLLTKC QIWSIVRKYM QKEGCAGEVV
VQLSEDLLSQ AVMMVENSRP TLAINLTGAR QYWLEGMLRH EIGTHYLRGV NNARQPWHNA
EGRLRYGLRP ANPTEEGLAS LHSVLFRKQP FLWRAALLYY TIHRAARMSF RQLFQDLERY
VQDADVRWEY CVRAKRGQTD TSLPGCFSKD QVYLDGIVRI LRHRQTIDFP LLTSLGKVSY
EDVDHLRPHG VLDNTRVPHF MQDLARYRQQ LEHIMATNRL DEAELGRLLP D
