ID   KA102_CENNO             Reviewed;          32 AA.
AC   P58504;
DT   19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   19-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Potassium channel toxin alpha-KTx 10.2;
DE   AltName: Full=Cobatoxin-2 {ECO:0000303|PubMed:9688256};
DE            Short=CoTx2 {ECO:0000303|PubMed:9688256};
OS   Centruroides noxius (Mexican scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Centruroides.
OX   NCBI_TaxID=6878;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=9688256; DOI=10.1046/j.1432-1327.1998.2540468.x;
RA   Selisko B., Garcia C., Becerril B., Gomez-Lagunas F., Garay C.,
RA   Possani L.D.;
RT   "Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a new
RT   subfamily of potassium-channel-blocking scorpion toxins.";
RL   Eur. J. Biochem. 254:468-479(1998).
CC   -!- FUNCTION: Blocks Shaker B potassium-channels (Kv1.1/KCNA1 sub-family).
CC       {ECO:0000269|PubMed:9688256}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9688256}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:9688256}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 10 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P58504; -.
DR   SMR; P58504; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS01138; SCORP_SHORT_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Toxin; Voltage-gated potassium channel impairing toxin.
FT   PEPTIDE         1..32
FT                   /note="Potassium channel toxin alpha-KTx 10.2"
FT                   /evidence="ECO:0000269|PubMed:9688256"
FT                   /id="PRO_0000044907"
FT   SITE            21
FT                   /note="Basic residue of the functional dyad"
FT                   /evidence="ECO:0000250"
FT   SITE            30
FT                   /note="Aromatic residue of the functional dyad"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         32
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250|UniProtKB:O46028"
FT   DISULFID        3..22
FT                   /evidence="ECO:0000250|UniProtKB:O46028"
FT   DISULFID        8..12
FT                   /evidence="ECO:0000250|UniProtKB:O46028"
FT   DISULFID        27..29
FT                   /evidence="ECO:0000250|UniProtKB:O46028"
SQ   SEQUENCE   32 AA;  3713 MW;  A390616E150839EF CRC64;
     VACVYRTCDK DCTSRKYRSG KCINNACKCY PY