ID   KA111_SCHPO             Reviewed;         990 AA.
AC   Q09796; Q9US85;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Importin beta-like protein kap111;
DE   AltName: Full=Karyopherin-111;
GN   Name=kap111; ORFNames=SPAC22G7.02;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 554-730, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA   Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA   Hiraoka Y.;
RT   "Large-scale screening of intracellular protein localization in living
RT   fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL   Genes Cells 5:169-190(2000).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15116432; DOI=10.1002/yea.1115;
RA   Chen X.Q., Du X., Liu J., Balasubramanian M.K., Balasundaram D.;
RT   "Identification of genes encoding putative nucleoporins and transport
RT   factors in the fission yeast Schizosaccharomyces pombe: a deletion
RT   analysis.";
RL   Yeast 21:495-509(2004).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors. Active directional transport is assured by both, a Phe-Gly
CC       (FG) repeat affinity gradient for these transport factors across the
CC       NPC and a transport cofactor concentration gradient across the nuclear
CC       envelope. {ECO:0000269|PubMed:15116432}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10759889,
CC       ECO:0000269|PubMed:15116432, ECO:0000269|PubMed:16823372}. Note=Nuclear
CC       rim.
CC   -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA91126.1; -; Genomic_DNA.
DR   EMBL; AB027978; BAA87282.1; -; Genomic_DNA.
DR   PIR; T11612; T11612.
DR   RefSeq; NP_593051.1; NM_001018449.2.
DR   AlphaFoldDB; Q09796; -.
DR   SMR; Q09796; -.
DR   BioGRID; 277969; 1.
DR   STRING; 4896.SPAC22G7.02.1; -.
DR   iPTMnet; Q09796; -.
DR   MaxQB; Q09796; -.
DR   PaxDb; Q09796; -.
DR   PRIDE; Q09796; -.
DR   EnsemblFungi; SPAC22G7.02.1; SPAC22G7.02.1:pep; SPAC22G7.02.
DR   GeneID; 2541467; -.
DR   KEGG; spo:SPAC22G7.02; -.
DR   PomBase; SPAC22G7.02; kap111.
DR   VEuPathDB; FungiDB:SPAC22G7.02; -.
DR   eggNOG; KOG2022; Eukaryota.
DR   HOGENOM; CLU_005271_0_0_1; -.
DR   InParanoid; Q09796; -.
DR   OMA; ITEQICH; -.
DR   PhylomeDB; Q09796; -.
DR   PRO; PR:Q09796; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR   GO; GO:0031965; C:nuclear membrane; HDA:PomBase.
DR   GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005525; F:GTP binding; NAS:PomBase.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; ISO:PomBase.
DR   GO; GO:0006606; P:protein import into nucleus; ISO:PomBase.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040520; Importin_rep_3.
DR   Pfam; PF18806; Importin_rep_3; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transport.
FT   CHAIN           1..990
FT                   /note="Importin beta-like protein kap111"
FT                   /id="PRO_0000116404"
FT   CONFLICT        728..730
FT                   /note="LIC -> VGD (in Ref. 2; BAA87282)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   990 AA;  111468 MW;  6B50A8DA33D3B81B CRC64;
     MDGNEIAHAK KLVYDLYSGS LSPSAIAATE KELQKAQRSQ QGWNIGLFML QSKDVYEQFF
     GALTLQMKIN TQLETLSDKD LVQLFVQLLQ KLLWDDGLPA LVERKVICTL ASLTIKYELE
     KKEEASLKVI YCLFCNKLEF FNADMNAASV LNNLFPPASS RNAQLTASYI NELLLELSFS
     IYTKENEDAL FNNVFRPCSN IIVSVLVFIF TNYSLDLSKE KNVAALEEAL NCMIAISSYL
     AKASVSVQSV LPAFTECMDL TVNCIALDEV SEKAMNCLAD LLANYSNFIT QPTIERLWTI
     LTGPWGETHL QQELEDPDSG EENDYSFLNI VIGFAEAMLP QIIDHIQEEK SIRLLYILAS
     LLSFPGYAIV EEKVSWRTLE FWTTLIEDFS MSKAATDPSK DEIFKQIAFS VVEKAWWKML
     LPSPEQWNSW PSSSRDSFNS YRRDLGDLLE SSYSIFGERL YAMYITTIEN FFSDGTGSPQ
     SLEVSFYCLC CILEYDTNDS DTLDAWLTRL FETSFAIKAS AFQNPQLLKT CSQLLSSCSC
     FLQNHPQYLN ISLPVLFDAL HISETSIQMT VSRSIHTLCT TCASHLLTEI DGFMAVVEEL
     TPKLVYVPSV LEKIYSSVGY VTQRIEDIEL RISYLMRLLN CILAQLQPSL YPNLEIFENV
     LKSCLQSVAG VALSQSPIGE SPIIDVEQST QETTFWQQSC IAEFQAKLIS FLTHSESMAL
     QYSDVVGLIC KIMIAGLNEV EPSPFSLPIV TTIQYFCDRF TEFPAAVLLT LGSAILTCPY
     GQTDIIDKVL IDMCSSIQNS VVIINEESFM NNIDITVELY HFFSIILQKH PSFLETMYPD
     FTQLILNRAI NLLGKPERLL ESAAGQFIIS FITSEKSDLL NTHTDFVNAI RSPLIAKILL
     GFGGNASRSS LPLLSDILGK LKAQNFSATR ACLTQSLEEE GFPSRNVSNE IKRRFLTDLL
     KARIKDKVKQ FWILCKGLES TPYGNSSWTF