ID   KA113_SCHPO             Reviewed;         983 AA.
AC   O94545;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Importin beta-like protein kap113;
DE   AltName: Full=Karyopherin-113;
GN   Name=kap113; ORFNames=SPCC1322.06;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15116432; DOI=10.1002/yea.1115;
RA   Chen X.Q., Du X., Liu J., Balasubramanian M.K., Balasundaram D.;
RT   "Identification of genes encoding putative nucleoporins and transport
RT   factors in the fission yeast Schizosaccharomyces pombe: a deletion
RT   analysis.";
RL   Yeast 21:495-509(2004).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors. Active directional transport is assured by both, a Phe-Gly
CC       (FG) repeat affinity gradient for these transport factors across the
CC       NPC and a transport cofactor concentration gradient across the nuclear
CC       envelope. Involved in the export of mRNA from the nucleus to the
CC       cytoplasm. May play a role in mitotic spindle formation and/or
CC       function. {ECO:0000269|PubMed:15116432}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15116432,
CC       ECO:0000269|PubMed:16823372}. Note=Nuclear rim.
CC   -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA22859.1; -; Genomic_DNA.
DR   PIR; T40937; T40937.
DR   RefSeq; NP_588134.1; NM_001023124.2.
DR   AlphaFoldDB; O94545; -.
DR   SMR; O94545; -.
DR   BioGRID; 275381; 40.
DR   STRING; 4896.SPCC1322.06.1; -.
DR   MaxQB; O94545; -.
DR   PaxDb; O94545; -.
DR   EnsemblFungi; SPCC1322.06.1; SPCC1322.06.1:pep; SPCC1322.06.
DR   GeneID; 2538800; -.
DR   KEGG; spo:SPCC1322.06; -.
DR   PomBase; SPCC1322.06; kap113.
DR   VEuPathDB; FungiDB:SPCC1322.06; -.
DR   eggNOG; KOG1993; Eukaryota.
DR   HOGENOM; CLU_003886_0_0_1; -.
DR   InParanoid; O94545; -.
DR   OMA; SFHYVFH; -.
DR   PhylomeDB; O94545; -.
DR   PRO; PR:O94545; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR   GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; ISO:PomBase.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IMP:PomBase.
DR   GO; GO:0006606; P:protein import into nucleus; ISO:PomBase.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   mRNA transport; Nucleus; Reference proteome; Transport.
FT   CHAIN           1..983
FT                   /note="Importin beta-like protein kap113"
FT                   /id="PRO_0000290666"
FT   DOMAIN          24..96
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ   SEQUENCE   983 AA;  112935 MW;  99A4B782DC768E3F CRC64;
     MQVDPVVYQL QRAVSQDPIA VKDAEGHLNN WKKEPGFFGK LYSIFLDKQN DMSLRWIAII
     QLRNSIDIIW RKNTKMSLLP EERDFIRCNA LLGSIKSENL LSIQNALVVS RIARLDYPTE
     WPSLFHDLLG KLQQSLGTGD YDVALRLLIT LHHIIKAMAG NRLLRSRQIF YKLAPELLTI
     LQPILHSSLS SWMMILESSK EIKDSTLLSY MQISRYTLKA CRRLVVFGFQ NPSESEFSER
     MLAFCAVHQR KLLSMLGTML QSSRSPIVVG ECLEMAFAHA FLFNKPFFDF SFYSPCLTKF
     PATIDYISLH YDFLGQISSH LSSYKEKFEE SSKNFEKLVI MSLRVFILVI QEFCNTKSSH
     PETAQVLYNS FLVDNRINNL LDLLITKLLI LKEEDFEEWT DSPQQWVLEQ STQDVEFNVR
     PCAEKLLKCF FDAYGDIIVS PFKDMIYSVF ECPKTLTQAV QQDTLISSFG VGYTQLKSIF
     PFAKWLQEAA VPNMASINDI GISRVYRRRI AIFLSQWIED SSSEQLLEVI YKLYCSFLNL
     TDPCNDAVVI LTTIDAFKTV LDDWNFSENS FLSIKENLFV HVLSLFKAFE SVDARTSILS
     LLGTLLARAG EHVAPMESTI ASLLSQLWDG WKKEPLLRAR VLAVMHQFVN AIKAKSFEFS
     TFLYTVIEYC VNPESPEHVI FEADAMELWS TFLMYIQKLP ETFTLLIPHL LYHLSQATST
     LPFVLMIVSS YQLLDNTVLM KDYSFTIFEK LNDLLDDVKN ETLQALCKTV CLLIETTPMD
     MIYESLLNSS LLSRLLLSIA TNDKHPQVLI EYLLVVSRIS LREPELILKV CQTKNINIAM
     LIGNWILLND HINHSKDRKL NTLALSSLLR TNHPDVLAVL DSIMNLWFSV LSEVEEDANG
     DATIYYKNDD YSAVGFYLDE TSEEMTRRKQ LLLKDPVHSV NSRSFFISVF MFCRDANGGM
     ENFQNQYLST VNPALLEQFQ SML