ID   KA141_MESMA             Reviewed;          54 AA.
AC   Q967F9;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Potassium channel toxin alpha-KTx 14.1;
DE   AltName: Full=BmKK1;
DE   AltName: Full=Toxin Kk1;
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hubei; TISSUE=Venom gland;
RX   PubMed=11698110; DOI=10.1016/s0300-9084(01)01326-8;
RA   Zeng X.-C., Peng F., Luo F., Zhu S.-Y., Liu H., Li W.-X.;
RT   "Molecular cloning and characterization of four scorpion K(+)-toxin-like
RT   peptides: a new subfamily of venom peptides (alpha-KTx14) and genomic
RT   analysis of a member.";
RL   Biochimie 83:883-889(2001).
CC   -!- FUNCTION: Potential blocker of potassium channels.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- PTM: Probably has three disulfide bridges. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 14 subfamily. {ECO:0000305}.
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DR   EMBL; AJ277726; CAC38035.1; -; mRNA.
DR   AlphaFoldDB; Q967F9; -.
DR   SMR; Q967F9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..54
FT                   /note="Potassium channel toxin alpha-KTx 14.1"
FT                   /id="PRO_0000035333"
SQ   SEQUENCE   54 AA;  5776 MW;  AF5AA64FDDDDC5C1 CRC64;
     MKIFFAILLI LAVCSMAIWT VNGTPFAIKC ATDADCSRKC PGNPSCRNGF CACT