ID   KA144_MESMA             Reviewed;          54 AA.
AC   Q9BKB4;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Potassium channel toxin alpha-KTx 14.4;
DE   AltName: Full=BmSKTx1;
DE   AltName: Full=Neurotoxin SKTx1;
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-45, FUNCTION, AND
RP   MASS SPECTROMETRY.
RC   STRAIN=Henan; TISSUE=Venom;
RX   PubMed=15208029; DOI=10.1016/j.toxicon.2004.01.018;
RA   Xu C.-Q., He L.-L., Brone B., Martin-Eauclaire M.-F., Van Kerkhove E.,
RA   Zhou Z., Chi C.-W.;
RT   "A novel scorpion toxin blocking small conductance Ca2+ activated K+
RT   channel.";
RL   Toxicon 43:961-971(2004).
CC   -!- FUNCTION: Selectively and reversibly inhibits small conductance
CC       calcium-activated potassium channels (KCNN, SK).
CC       {ECO:0000269|PubMed:15208029}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3242.0; Method=Unknown;
CC       Evidence={ECO:0000269|PubMed:15208029};
CC   -!- MISCELLANEOUS: Has no effect on sodium, calcium, Kv nor BK currents.
CC       Does not affect apamin binding (PubMed:15208029).
CC       {ECO:0000305|PubMed:15208029}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 14 subfamily. {ECO:0000305}.
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DR   EMBL; AF295594; AAK31986.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9BKB4; -.
DR   SMR; Q9BKB4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   Calcium-activated potassium channel impairing toxin;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:15208029"
FT   CHAIN           24..54
FT                   /note="Potassium channel toxin alpha-KTx 14.4"
FT                   /id="PRO_0000227815"
FT   DISULFID        30..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   54 AA;  5785 MW;  AF59694FDDD0A8A1 CRC64;
     MKIFFAILLI LAVCSMAIWT VNGTPFAIKC ATNADCSRKC PGNPPCRNGF CACT