ID   KA145_MESGB             Reviewed;          54 AA.
AC   A0A059U906;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   03-SEP-2014, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Potassium channel toxin alpha-KTx 14.5 {ECO:0000303|PubMed:24746279};
DE   AltName: Full=Toxin Mgib29 {ECO:0000303|PubMed:24746279};
DE   Flags: Precursor;
OS   Mesobuthus gibbosus (Mediterranean checkered scorpion) (Buthus gibbosus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=123226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND NOMENCLATURE.
RC   TISSUE=Venom gland;
RX   PubMed=24746279; DOI=10.1186/1471-2164-15-295;
RA   Diego-Garcia E., Caliskan F., Tytgat J.;
RT   "The Mediterranean scorpion Mesobuthus gibbosus (Scorpiones, Buthidae):
RT   transcriptome analysis and organization of the genome encoding chlorotoxin-
RT   like peptides.";
RL   BMC Genomics 15:295-295(2014).
CC   -!- FUNCTION: Inhibits potassium channels. May be active towards small
CC       conductance calcium-activated potassium channels (KCNN, SK), and less
CC       active towards voltage-gated potassium channels (Kv/KCN).
CC       {ECO:0000250|UniProtKB:Q95NK7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q95NK7}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta).
CC       {ECO:0000250|UniProtKB:Q95NK7}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 14 subfamily. {ECO:0000305}.
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DR   EMBL; KF770827; AHZ63136.1; -; mRNA.
DR   AlphaFoldDB; A0A059U906; -.
DR   SMR; A0A059U906; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   3: Inferred from homology;
KW   Calcium-activated potassium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin; Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250|UniProtKB:Q95NK7"
FT   CHAIN           24..54
FT                   /note="Potassium channel toxin alpha-KTx 14.5"
FT                   /id="PRO_0000433144"
FT   DISULFID        30..46
FT                   /evidence="ECO:0000250|UniProtKB:Q95NK7"
FT   DISULFID        36..51
FT                   /evidence="ECO:0000250|UniProtKB:Q95NK7"
FT   DISULFID        40..53
FT                   /evidence="ECO:0000250|UniProtKB:Q95NK7"
SQ   SEQUENCE   54 AA;  5951 MW;  F35DE626C3DC25CC CRC64;
     MKIFFAILLI LAVCSMAIWT VNGTPFAIRC KTDSDCSYKC PGNPPCRNGF CKCT