ID   KA14_MESMA              Reviewed;          54 AA.
AC   A0ASK0;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Potassium channel toxin alpha-KTx 14.x;
DE   AltName: Full=BmKK14;
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hubei; TISSUE=Venom gland;
RX   PubMed=16081373; DOI=10.1080/15216540500149870;
RA   Cao Z., Mao X., Xu X., Sheng J., Dai C., Wu Y., Luo F., Sha Y., Jiang D.,
RA   Li W.;
RT   "Adaptive evolution after gene duplication in alpha-KT x 14 subfamily from
RT   Buthus martensii Karsch.";
RL   IUBMB Life 57:513-521(2005).
CC   -!- FUNCTION: Potassium channels inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta).
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 14 subfamily. {ECO:0000305}.
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DR   EMBL; AY730620; AAW62366.1; -; mRNA.
DR   AlphaFoldDB; A0ASK0; -.
DR   SMR; A0ASK0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..54
FT                   /note="Potassium channel toxin alpha-KTx 14.x"
FT                   /id="PRO_5000147972"
FT   DISULFID        30..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   54 AA;  5842 MW;  AF5FE7D37299C5C1 CRC64;
     MKIFFAILLI LAVCSMAIWT VNGTPFEVRC ATDADCARKC PGNPPCRNGF CACT