ID   KA161_HOTTA             Reviewed;          36 AA.
AC   P0C173;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Potassium channel toxin alpha-KTx 16.1;
DE   AltName: Full=Alpha-KTx 1.8;
DE   AltName: Full=Tamulotoxin;
DE            Short=TmTX;
OS   Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34647;
RN   [1]
RP   PROTEIN SEQUENCE, AND SYNTHESIS.
RC   TISSUE=Venom;
RA   Escoubas P., Romi-Lebrun R., Lebrun B., Herrmann R., Moskowitz H.,
RA   Rajendra W., Hammock B., Nakajima T.;
RT   "Tamulotoxin, a novel member of potassium channel active short toxins from
RT   the venom of the indian red scorpion Buthus tamulus.";
RL   Toxicon 35:806-806(1997).
CC   -!- FUNCTION: Blocks calcium-activated potassium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 16 subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C173; -.
DR   SMR; P0C173; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR   Pfam; PF00451; Toxin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS01138; SCORP_SHORT_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Calcium-activated potassium channel impairing toxin;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin.
FT   CHAIN           1..36
FT                   /note="Potassium channel toxin alpha-KTx 16.1"
FT                   /id="PRO_0000227816"
FT   SITE            27
FT                   /note="Basic residue of the functional dyad"
FT                   /evidence="ECO:0000250"
FT   SITE            36
FT                   /note="Aromatic residue of the functional dyad"
FT                   /evidence="ECO:0000250"
FT   DISULFID        7..28
FT                   /evidence="ECO:0000250"
FT   DISULFID        13..33
FT                   /evidence="ECO:0000250"
FT   DISULFID        17..35
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   36 AA;  4213 MW;  D0F40011658569F6 CRC64;
     DLIDVKCISS QECWIACKKV TGRFEGKCQN RQCRCY