ID   KA201_TITTR             Reviewed;          29 AA.
AC   P0C183;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Potassium channel toxin alpha-KTx 20.1;
DE   AltName: Full=Toxin Tt28;
OS   Tityus trivittatus (Argentinean scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=369776;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=16405970; DOI=10.1016/j.febslet.2005.12.073;
RA   Abdel-Mottaleb Y., Coronas F.V., de Roodt A.R., Possani L.D., Tytgat J.;
RT   "A novel toxin from the venom of the scorpion Tityus trivittatus, is the
RT   first member of a new alpha-KTX subfamily.";
RL   FEBS Lett. 580:592-596(2006).
CC   -!- FUNCTION: Reduces potassium currents through Kv1.2/KCNA2 and
CC       Kv1.3/KCNA3 voltage-gated potassium channels.
CC       {ECO:0000269|PubMed:16405970}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3310.3; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16405970};
CC   -!- MISCELLANEOUS: Has no effect on Kv1.1/KCNA1, Kv1.4/KCNA4, Kv1.5/KCNA5,
CC       shaker IR or Kv11.1/KCNH2 channels. {ECO:0000305|PubMed:16405970}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 20 subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C183; -.
DR   SMR; P0C183; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   PEPTIDE         1..29
FT                   /note="Potassium channel toxin alpha-KTx 20.1"
FT                   /id="PRO_0000228824"
FT   DISULFID        2..20
FT                   /evidence="ECO:0000250"
FT   DISULFID        7..24
FT                   /evidence="ECO:0000250"
FT   DISULFID        11..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   29 AA;  3316 MW;  13C6D9D2E7A25CD0 CRC64;
     GCTPEYCSMW CKVKVSQNYC VKNCKCPGR