ID   KA271_BUTOS             Reviewed;          73 AA.
AC   B8XH44;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Potassium channel toxin alpha-KTx 27.1 {ECO:0000303|PubMed:24746279};
DE   AltName: Full=Toxin BoiTx771 {ECO:0000303|Ref.1};
DE            Short=Toxin Tx771 {ECO:0000303|Ref.1};
DE   Flags: Precursor;
OS   Buthus occitanus israelis (Common yellow scorpion) (Buthus israelis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Buthus.
OX   NCBI_TaxID=539894;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Zilberberg N., Kozminsky-Atias A.;
RT   "Buthus occitanus israelis scorpion toxin.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=24746279; DOI=10.1186/1471-2164-15-295;
RA   Diego-Garcia E., Caliskan F., Tytgat J.;
RT   "The Mediterranean scorpion Mesobuthus gibbosus (Scorpiones, Buthidae):
RT   transcriptome analysis and organization of the genome encoding chlorotoxin-
RT   like peptides.";
RL   BMC Genomics 15:295-295(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 27 subfamily. {ECO:0000305}.
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DR   EMBL; FJ360833; ACJ23153.1; -; mRNA.
DR   AlphaFoldDB; B8XH44; -.
DR   SMR; B8XH44; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR   Pfam; PF00451; Toxin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS01138; SCORP_SHORT_TOXIN; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..73
FT                   /note="Potassium channel toxin alpha-KTx 27.1"
FT                   /id="PRO_0000433149"
SQ   SEQUENCE   73 AA;  8218 MW;  CB39A94BD58A41AE CRC64;
     MKFLFLTLFV CCFIAVLVIP SEAQIDINVS CRYGSDCAEP CKRLKCLLPS KCINGKCTCY
     PSIKIKNCKV QTY