ID   KA273_LYCMC             Reviewed;          66 AA.
AC   P0CI84;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Potassium channel toxin alpha-KTx 27.3 {ECO:0000303|PubMed:24746279};
DE   AltName: Full=Putative neurotoxin-C {ECO:0000303|PubMed:20663230};
DE   Flags: Precursor;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Yunnan; TISSUE=Venom gland;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=24746279; DOI=10.1186/1471-2164-15-295;
RA   Diego-Garcia E., Caliskan F., Tytgat J.;
RT   "The Mediterranean scorpion Mesobuthus gibbosus (Scorpiones, Buthidae):
RT   transcriptome analysis and organization of the genome encoding chlorotoxin-
RT   like peptides.";
RL   BMC Genomics 15:295-295(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 27 subfamily. {ECO:0000305}.
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DR   EMBL; GT028654; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0CI84; -.
DR   SMR; P0CI84; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..66
FT                   /note="Potassium channel toxin alpha-KTx 27.3"
FT                   /id="PRO_0000403835"
SQ   SEQUENCE   66 AA;  7480 MW;  00DE14FEA5D8E21D CRC64;
     MKLMWLLFLC VLAFSIAQIY ISDPCAGGVH RCYEPCEKKK CRLPHKCING RCTCYVGRNV
     CAISSH