ID   KA293_LYCMC             Reviewed;          60 AA.
AC   P0CI86;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   03-AUG-2022, entry version 18.
DE   RecName: Full=Potassium channel toxin alpha-KTx 29.3;
DE   AltName: Full=Neurotoxin LmKTx95;
DE   AltName: Full=Neurotoxin-E;
DE   Flags: Precursor;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Yunnan; TISSUE=Venom gland;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=22511981; DOI=10.1371/journal.pone.0035154;
RA   Chen Z.Y., Zeng D.Y., Hu Y.T., He Y.W., Pan N., Ding J.P., Cao Z.J.,
RA   Liu M.L., Li W.X., Yi H., Jiang L., Wu Y.L.;
RT   "Structural and functional diversity of acidic scorpion potassium channel
RT   toxins.";
RL   PLoS ONE 7:E35154-E35154(2012).
CC   -!- FUNCTION: Weakly inhibits the Kv1.3/KCNA3 channel (1 uM of thetoxin
CC       inhibits currents by 13.2%) and Kv7.1/KCNQ1 channel (10 uM of the toxin
CC       inhibits currents by 27.7%). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 29 subfamily. {ECO:0000305}.
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DR   EMBL; GT028769; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0CI86; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..60
FT                   /note="Potassium channel toxin alpha-KTx 29.3"
FT                   /id="PRO_0000403837"
FT   DISULFID        32..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..58
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   60 AA;  6267 MW;  0EBFE74BFD353BC2 CRC64;
     MKSVCGVLII LVVLTTMLSI STFSTVGAEA DCPISEAIKC VEKCNQKVEV CEPGVCKCSG