KAAG1_HUMAN
ID KAAG1_HUMAN Reviewed; 84 AA.
AC Q9UBP8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Kidney-associated antigen 1;
DE AltName: Full=RU2 antisense gene protein;
GN Name=KAAG1; Synonyms=RU2AS;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10601354; DOI=10.1084/jem.190.12.1793;
RA Van den Eynde B.J., Gaugler B., Probst-Kepper M., Michaux L., Devuyst O.,
RA Lorge F., Weynants P., Boon T.;
RT "A new antigen recognized by cytolytic T lymphocytes on a human kidney
RT tumor results from reverse strand transcription.";
RL J. Exp. Med. 190:1793-1800(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
CC -!- TISSUE SPECIFICITY: Expressed in testis and kidney, and, at lower
CC levels, in urinary bladder and liver. Expressed by a high proportion of
CC tumors of various histologic origin, including melanomas, sarcomas and
CC colorectal carcinomas. {ECO:0000269|PubMed:10601354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF181720; AAF23611.1; -; Genomic_DNA.
DR EMBL; AF181722; AAF23613.1; -; mRNA.
DR EMBL; AL359713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_851854.1; NM_181337.3.
DR AlphaFoldDB; Q9UBP8; -.
DR BioGRID; 131666; 8.
DR STRING; 9606.ENSP00000274766; -.
DR BioMuta; KAAG1; -.
DR MassIVE; Q9UBP8; -.
DR PaxDb; Q9UBP8; -.
DR PRIDE; Q9UBP8; -.
DR Antibodypedia; 25266; 14 antibodies from 9 providers.
DR DNASU; 353219; -.
DR Ensembl; ENST00000274766.2; ENSP00000274766.1; ENSG00000146049.2.
DR GeneID; 353219; -.
DR KEGG; hsa:353219; -.
DR MANE-Select; ENST00000274766.2; ENSP00000274766.1; NM_181337.4; NP_851854.1.
DR UCSC; uc003ndz.1; human.
DR CTD; 353219; -.
DR DisGeNET; 353219; -.
DR GeneCards; KAAG1; -.
DR HGNC; HGNC:21031; KAAG1.
DR HPA; ENSG00000146049; Tissue enhanced (kidney, pancreas).
DR MalaCards; KAAG1; -.
DR MIM; 608211; gene.
DR neXtProt; NX_Q9UBP8; -.
DR OpenTargets; ENSG00000146049; -.
DR PharmGKB; PA134915618; -.
DR VEuPathDB; HostDB:ENSG00000146049; -.
DR eggNOG; ENOG502TDZF; Eukaryota.
DR GeneTree; ENSGT00390000011791; -.
DR HOGENOM; CLU_2573189_0_0_1; -.
DR InParanoid; Q9UBP8; -.
DR OMA; APCEEGV; -.
DR OrthoDB; 1641183at2759; -.
DR PhylomeDB; Q9UBP8; -.
DR TreeFam; TF340885; -.
DR PathwayCommons; Q9UBP8; -.
DR SignaLink; Q9UBP8; -.
DR BioGRID-ORCS; 353219; 15 hits in 978 CRISPR screens.
DR GenomeRNAi; 353219; -.
DR Pharos; Q9UBP8; Tdark.
DR PRO; PR:Q9UBP8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9UBP8; protein.
DR Bgee; ENSG00000146049; Expressed in metanephros cortex and 25 other tissues.
DR Genevisible; Q9UBP8; HS.
DR GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR InterPro; IPR029407; KAAG1.
DR Pfam; PF15354; KAAG1; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..84
FT /note="Kidney-associated antigen 1"
FT /id="PRO_0000274669"
FT REGION 31..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 84 AA; 8969 MW; 70B739F173A9E560 CRC64;
MDDDAAPRVE GVPVAVHKHA LHDGLRQVAG PGAAAAHLPR WPPPQLAASR REAPPLSQRP
HRTQGAGSPP ETNEKLTNPQ VKEK