ID   KABS_OLDAF              Reviewed;          29 AA.
AC   P58458;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Kalata-S;
OS   Oldenlandia affinis.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Gentianales; Rubiaceae; Rubioideae; Spermacoceae;
OC   Hedyotis-Oldenlandia complex; Oldenlandia.
OX   NCBI_TaxID=60225;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=10600388; DOI=10.1006/jmbi.1999.3383;
RA   Craik D.J., Daly N.L., Bond T., Waine C.;
RT   "Plant cyclotides: a unique family of cyclic and knotted proteins that
RT   defines the cyclic cystine knot structural motif.";
RL   J. Mol. Biol. 294:1327-1336(1999).
CC   -!- FUNCTION: Probably participates in a plant defense mechanism.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC   -!- PTM: This is a cyclic peptide.
CC   -!- SIMILARITY: Belongs to the cyclotide family. Moebius subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00395}.
CC   -!- CAUTION: This peptide is cyclic. The start position was chosen by
CC       similarity to OAK1 (kalata-B1) for which the DNA sequence is known.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P58458; -.
DR   SMR; P58458; -.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR005535; Cyclotide.
DR   InterPro; IPR012324; Cyclotide_moebius_CS.
DR   InterPro; IPR036146; Cyclotide_sf.
DR   Pfam; PF03784; Cyclotide; 1.
DR   PIRSF; PIRSF037891; Cycloviolacin; 1.
DR   SUPFAM; SSF57038; SSF57038; 1.
DR   PROSITE; PS51052; CYCLOTIDE; 1.
DR   PROSITE; PS60009; CYCLOTIDE_MOEBIUS; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Plant defense.
FT   PEPTIDE         1..29
FT                   /note="Kalata-S"
FT                   /id="PRO_0000043631"
FT   DISULFID        5..19
FT   DISULFID        9..21
FT   DISULFID        14..26
FT   CROSSLNK        1..29
FT                   /note="Cyclopeptide (Gly-Asn)"
SQ   SEQUENCE   29 AA;  2902 MW;  3228B0EE3F82FA18 CRC64;
     GLPVCGETCV GGTCNTPGCS CSWPVCTRN