APT_PSEAE
ID APT_PSEAE Reviewed; 182 AA.
AC Q04633;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Adenine phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_00004};
DE Short=APRT {ECO:0000255|HAMAP-Rule:MF_00004};
DE EC=2.4.2.7 {ECO:0000255|HAMAP-Rule:MF_00004};
GN Name=apt {ECO:0000255|HAMAP-Rule:MF_00004}; OrderedLocusNames=PA1543;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RA Savioz A., Zimmermann A., Haas D.;
RT "RpoN-independent promoters having a conserved GG-N10-GC motif in
RT Pseudomonas aeruginosa.";
RL Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=1787798; DOI=10.1111/j.1365-2958.1991.tb00794.x;
RA Zimmermann A., Reimmann C., Galimand M., Haas D.;
RT "Anaerobic growth and cyanide synthesis of Pseudomonas aeruginosa depend on
RT anr, a regulatory gene homologous with fnr of Escherichia coli.";
RL Mol. Microbiol. 5:1483-1490(1991).
CC -!- FUNCTION: Catalyzes a salvage reaction resulting in the formation of
CC AMP, that is energically less costly than de novo synthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00004}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate +
CC adenine; Xref=Rhea:RHEA:16609, ChEBI:CHEBI:16708, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58017, ChEBI:CHEBI:456215; EC=2.4.2.7;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00004};
CC -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC from adenine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00004}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00004}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00004}.
CC -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC family. {ECO:0000255|HAMAP-Rule:MF_00004}.
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DR EMBL; M98276; AAA25714.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG04932.1; -; Genomic_DNA.
DR EMBL; X57736; CAA40907.1; -; Genomic_DNA.
DR PIR; F83453; F83453.
DR RefSeq; NP_250234.1; NC_002516.2.
DR RefSeq; WP_003087259.1; NZ_QZGE01000032.1.
DR AlphaFoldDB; Q04633; -.
DR SMR; Q04633; -.
DR STRING; 287.DR97_393; -.
DR PaxDb; Q04633; -.
DR PRIDE; Q04633; -.
DR EnsemblBacteria; AAG04932; AAG04932; PA1543.
DR GeneID; 879394; -.
DR KEGG; pae:PA1543; -.
DR PATRIC; fig|208964.12.peg.1596; -.
DR PseudoCAP; PA1543; -.
DR HOGENOM; CLU_063339_3_0_6; -.
DR InParanoid; Q04633; -.
DR OMA; KPGIVFR; -.
DR PhylomeDB; Q04633; -.
DR BioCyc; PAER208964:G1FZ6-1571-MON; -.
DR UniPathway; UPA00588; UER00646.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003999; F:adenine phosphoribosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006168; P:adenine salvage; IEA:UniProtKB-UniRule.
DR GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR HAMAP; MF_00004; Aden_phosphoribosyltr; 1.
DR InterPro; IPR005764; Ade_phspho_trans.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR Pfam; PF00156; Pribosyltran; 1.
DR SUPFAM; SSF53271; SSF53271; 1.
DR TIGRFAMs; TIGR01090; apt; 1.
DR PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Glycosyltransferase; Purine salvage; Reference proteome;
KW Transferase.
FT CHAIN 1..182
FT /note="Adenine phosphoribosyltransferase"
FT /id="PRO_0000149433"
SQ SEQUENCE 182 AA; 19805 MW; 03525B50504E30F7 CRC64;
MIFDEFTLKS QIRAVPDFPK PGVVFRDITP LFQSPRALRM TVDSFVQRYI EADFSHIGAM
DARGFLIGSA VAYALNKPLV LFRKQGKLPA DVLAEGYQTE YGEAFLEVHA DSLCEGDSVL
IFDDLIATGG TLLAAASLVR RLGARVFEAA AIIDLPELGG STRLQDAGIS TFSLTAFALD
ER
