ID   KACA_RAT                Reviewed;         106 AA.
AC   P01836;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Ig kappa chain C region, A allele;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DA;
RX   PubMed=6273908; DOI=10.1073/pnas.78.11.7064;
RA   Sheppard H.W., Gutman G.A.;
RT   "Allelic forms of rat kappa chain genes: evidence for strong selection at
RT   the level of nucleotide sequence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:7064-7068(1981).
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DR   PIR; A02118; K1RTA.
DR   PDB; 2ARJ; X-ray; 2.88 A; A/L=1-103.
DR   PDB; 3B9K; X-ray; 2.70 A; C/L=1-106.
DR   PDBsum; 2ARJ; -.
DR   PDBsum; 3B9K; -.
DR   AlphaFoldDB; P01836; -.
DR   SMR; P01836; -.
DR   PRIDE; P01836; -.
DR   RGD; 1562743; LOC500183.
DR   InParanoid; P01836; -.
DR   PhylomeDB; P01836; -.
DR   EvolutionaryTrace; P01836; -.
DR   PRO; PR:P01836; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0071735; C:IgG immunoglobulin complex; ISO:RGD.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; ISO:RGD.
DR   GO; GO:0030183; P:B cell differentiation; ISO:RGD.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Immunoglobulin domain; Reference proteome.
FT   CHAIN           <1..106
FT                   /note="Ig kappa chain C region, A allele"
FT                   /id="PRO_0000153604"
FT   DOMAIN          5..102
FT                   /note="Ig-like"
FT   DISULFID        26..86
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        106
FT                   /note="Interchain (with a heavy chain)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
SQ   SEQUENCE   106 AA;  11732 MW;  B7E120D9700DDD66 CRC64;
     ADAAPTVSIF PPSMEQLTSG GATVVCFVNN FYPRDISVKW KIDGSEQRDG VLDSVTDQDS
     KDSTYSMSST LSLTKVEYER HNLYTCEVVH KTSSSPVVKS FNRNEC