位置:首页 > 蛋白库 > KAD6_RAT
KAD6_RAT
ID   KAD6_RAT                Reviewed;         172 AA.
AC   Q5EB68; A6XB81;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Adenylate kinase isoenzyme 6 {ECO:0000255|HAMAP-Rule:MF_03173};
DE            Short=AK6 {ECO:0000255|HAMAP-Rule:MF_03173};
DE            EC=2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_03173};
DE   AltName: Full=Coilin-interacting nuclear ATPase protein {ECO:0000255|HAMAP-Rule:MF_03173};
DE   AltName: Full=Dual activity adenylate kinase/ATPase {ECO:0000255|HAMAP-Rule:MF_03173};
DE            Short=AK/ATPase {ECO:0000255|HAMAP-Rule:MF_03173};
GN   Name=Ak6; Synonyms=Cinap;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=SHRSP;
RA   Miyoshi K., Sawatari M., Noma T.;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Broad-specificity nucleoside monophosphate (NMP) kinase that
CC       catalyzes the reversible transfer of the terminal phosphate group
CC       between nucleoside triphosphates and monophosphates. May have a role in
CC       nuclear energy homeostasis. Has also ATPase activity. May be involved
CC       in regulation of Cajal body (CB) formation. {ECO:0000255|HAMAP-
CC       Rule:MF_03173}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_03173};
CC   -!- SUBUNIT: Monomer and homodimer. Interacts with COIL (via C-terminus).
CC       {ECO:0000255|HAMAP-Rule:MF_03173}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC       Rule:MF_03173}. Nucleus, Cajal body {ECO:0000255|HAMAP-Rule:MF_03173}.
CC       Note=Displays widespread diffuse nucleoplasmic distribution but not
CC       detected in nucleoli. Detected in Cajal bodies but not in all cells.
CC       {ECO:0000255|HAMAP-Rule:MF_03173}.
CC   -!- SIMILARITY: Belongs to the adenylate kinase family. AK6 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03173}.
CC   -!- CAUTION: AK6 and TAF9 were initially considered as products of the same
CC       gene since they share two exons. However, they are translated from
CC       different initiation codons and reading frames and encode unrelated
CC       proteins. This arrangement is conserved in some mammalian species.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ323055; ABC50104.1; -; mRNA.
DR   EMBL; BC089989; AAH89989.1; -; mRNA.
DR   RefSeq; NP_001012481.1; NM_001012463.3.
DR   AlphaFoldDB; Q5EB68; -.
DR   SMR; Q5EB68; -.
DR   STRING; 10116.ENSRNOP00000057879; -.
DR   iPTMnet; Q5EB68; -.
DR   PhosphoSitePlus; Q5EB68; -.
DR   PaxDb; Q5EB68; -.
DR   GeneID; 102238592; -.
DR   KEGG; rno:102238592; -.
DR   CTD; 102157402; -.
DR   RGD; 7387335; Ak6.
DR   VEuPathDB; HostDB:ENSRNOG00000063018; -.
DR   eggNOG; KOG3347; Eukaryota.
DR   HOGENOM; CLU_079096_3_1_1; -.
DR   OMA; QCEIFGT; -.
DR   Reactome; R-RNO-499943; Interconversion of nucleotide di- and triphosphates.
DR   PRO; PR:Q5EB68; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000039848; Expressed in thymus and 19 other tissues.
DR   ExpressionAtlas; Q5EB68; baseline and differential.
DR   Genevisible; Q5EB68; RN.
DR   GO; GO:0015030; C:Cajal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004017; F:adenylate kinase activity; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00039; Adenylate_kinase_AK6; 1.
DR   InterPro; IPR020618; Adenyl_kinase_AK6.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12595; PTHR12595; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   Transferase.
FT   CHAIN           1..172
FT                   /note="Adenylate kinase isoenzyme 6"
FT                   /id="PRO_0000153899"
FT   REGION          33..56
FT                   /note="NMP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03173"
FT   REGION          108..118
FT                   /note="LID"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03173"
FT   BINDING         13..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03173"
FT   BINDING         39
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03173"
FT   BINDING         79
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03173"
FT   BINDING         105
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03173"
FT   BINDING         109
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03173"
FT   BINDING         148..149
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03173"
SQ   SEQUENCE   172 AA;  19944 MW;  A054FA201C1ED587 CRC64;
     MKLPNILLTG TPGVGKTTLG KELASRSGLK YVNVGDLARE GHLYDGYDEE YGCPILDEDR
     VVDELEPQMT EGGVIVDYHG CDFFPERWFH IVFVLRTDNG ILYKRLETRG YHEKKLQDNI
     QCEIFQVLYE EAMASYKEEI VHQLPSNEPE QLEDNINQIS KWIEQWVKDH NP
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024