ID   KADA_AERPE              Reviewed;         202 AA.
AC   Q9YDD2;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Adenylate kinase;
DE            Short=AK;
DE            EC=2.7.4.3;
DE   AltName: Full=ATP-AMP transphosphorylase;
GN   Name=adkA; OrderedLocusNames=APE_0981.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the archaeal adenylate kinase family.
CC       {ECO:0000305}.
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DR   EMBL; BA000002; BAA79965.2; -; Genomic_DNA.
DR   PIR; E72695; E72695.
DR   PDB; 6LN3; X-ray; 2.00 A; A=1-202.
DR   PDBsum; 6LN3; -.
DR   AlphaFoldDB; Q9YDD2; -.
DR   SMR; Q9YDD2; -.
DR   STRING; 272557.APE_0981.1; -.
DR   EnsemblBacteria; BAA79965; BAA79965; APE_0981.1.
DR   KEGG; ape:APE_0981.1; -.
DR   eggNOG; arCOG01039; Archaea.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004017; F:adenylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00234; Adenylate_kinase_AdkA; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR023477; Adenylate_kinase_AdkA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..202
FT                   /note="Adenylate kinase"
FT                   /id="PRO_0000131812"
FT   BINDING         12..20
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   STRAND          4..11
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   HELIX           18..31
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   STRAND          35..40
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   HELIX           41..51
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   HELIX           58..63
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   HELIX           66..87
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   STRAND          92..97
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   STRAND          100..104
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   STRAND          107..112
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   HELIX           114..120
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   STRAND          123..129
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   HELIX           132..141
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   HELIX           148..150
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   HELIX           152..171
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   TURN            172..175
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   STRAND          177..182
FT                   /evidence="ECO:0007829|PDB:6LN3"
FT   HELIX           188..199
FT                   /evidence="ECO:0007829|PDB:6LN3"
SQ   SEQUENCE   202 AA;  21948 MW;  41E55846683A0891 CRC64;
     MRHPFKVVVV TGVPGVGKTT VIKELQGLAE KEGVKLHIVN FGSFMLDTAV KLGLVEDRDK
     IRTLPLRRQL ELQREAAKRI VAEASKALGG DGVLIIDTHA LVKTVAGYWP GLPKHVLDEL
     KPDMIAVVEA SPEEVAARQA RDTTRYRVDI GGVEGVKRLM ENARAASIAS AIQYASTVAI
     VENREGEAAK AAEELLRLIK NL