KADL_PLAF7
ID KADL_PLAF7 Reviewed; 263 AA.
AC C0H582;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Inactive adenylate kinase {ECO:0000305};
DE AltName: Full=Adenylate kinase-like protein 2 {ECO:0000303|PubMed:22819813};
GN Name=AKLP2 {ECO:0000303|PubMed:22819813};
GN ORFNames=PF3D7_0931900 {ECO:0000312|EMBL:CAX64260.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000312|Proteomes:UP000001450};
RN [1] {ECO:0000312|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7 {ECO:0000312|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000312|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7 {ECO:0000312|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP FUNCTION, LACK OF CATALYTIC ACTIVITY, AND SUBCELLULAR LOCATION.
RX PubMed=22819813; DOI=10.1016/j.febslet.2012.07.013;
RA Ma J., Rahlfs S., Jortzik E., Schirmer R.H., Przyborski J.M., Becker K.;
RT "Subcellular localization of adenylate kinases in Plasmodium falciparum.";
RL FEBS Lett. 586:3037-3043(2012).
CC -!- FUNCTION: Lacks adenylate kinase activity.
CC {ECO:0000269|PubMed:22819813}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22819813}.
CC -!- SIMILARITY: Belongs to the adenylate kinase family. {ECO:0000305}.
CC -!- CAUTION: Although it belongs to the adenylate kinase family, lacks
CC several residues involved in ATP and AMP binding and has no adenylate
CC kinase activity. {ECO:0000269|PubMed:22819813}.
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DR EMBL; AL844508; CAX64260.1; -; Genomic_DNA.
DR RefSeq; XP_002808979.1; XM_002808933.1.
DR AlphaFoldDB; C0H582; -.
DR SMR; C0H582; -.
DR STRING; 5833.PFI1550c; -.
DR EnsemblProtists; CAX64260; CAX64260; PF3D7_0931900.
DR GeneID; 813590; -.
DR KEGG; pfa:PF3D7_0931900; -.
DR VEuPathDB; PlasmoDB:PF3D7_0931900; -.
DR HOGENOM; CLU_1067407_0_0_1; -.
DR InParanoid; C0H582; -.
DR OMA; YHLSASH; -.
DR PhylomeDB; C0H582; -.
DR Proteomes; UP000001450; Chromosome 9.
DR GO; GO:0005829; C:cytosol; IDA:CACAO.
DR GO; GO:0004017; F:adenylate kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..263
FT /note="Inactive adenylate kinase"
FT /id="PRO_0000455422"
SQ SEQUENCE 263 AA; 31095 MW; BC3F168B553FFBD5 CRC64;
METLLHSEIL KKYKEETNEY IKKKNVEKLF DIILKNVLIN KPDNIYLYIY NNIYSFLLNK
IFIMGPPVLK ITSMLSSHIS EFFNYYHISL PILIQQYKLN KGESSNNKII VNDEIISFIL
KENIHNLDSK KKKGYIVEGY PNNNLQAYSC LKYLPSHVFV LYADEEYIYK KYEEENDIAI
FSYTQKKDYD INEPHEINNI DVKPLKDQVL SYIRNISDML TILGTNKKVL NLHDFNDQML
IDHVKNEVSK NKDEWDSTLN GDI
