ID   KAMC_SACHI              Reviewed;         156 AA.
AC   P25919;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=rRNA methyltransferase;
DE            EC=2.1.1.-;
DE   AltName: Full=Kanamycin-apramycin resistance methylase;
GN   Name=kamC;
OS   Saccharopolyspora hirsuta.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=1837;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CL102;
RX   PubMed=1840536; DOI=10.1016/0378-1119(91)90532-g;
RA   Holmes D.J., Drocourt D., Tiraby G., Cundiffe E.;
RT   "Cloning of an aminoglycoside-resistance-encoding gene, kamC, from
RT   Saccharopolyspora hirsuta: comparison with kamB from Streptomyces
RT   tenebrarius.";
RL   Gene 102:19-26(1991).
CC   -!- FUNCTION: Modifies 16S rRNA so making ribosomes resistant to certain
CC       aminoglycosides.
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DR   EMBL; M64626; AAA26499.1; -; Genomic_DNA.
DR   PIR; JQ1138; JQ1138.
DR   AlphaFoldDB; P25919; -.
DR   SMR; P25919; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
PE   4: Predicted;
KW   Antibiotic resistance; Methyltransferase; Transferase.
FT   CHAIN           1..156
FT                   /note="rRNA methyltransferase"
FT                   /id="PRO_0000068565"
SQ   SEQUENCE   156 AA;  16757 MW;  CBA5C77491FD9DC8 CRC64;
     MQKIAGKAAA SPKKGGAPNL LCVWASAEKP PPELARVTEL HSLMPWGSLL RGMLGSDTEM
     RPGLAELCVP GAEFLITLNL HAWRPPVPEV GDHPEPTPES AMELLAPYYA AAGWTLEEAR
     YFGAEELDAL ATSWTRRLGS TRDELDVLGI TGVIGK