KAN1_ARATH
ID KAN1_ARATH Reviewed; 403 AA.
AC Q93WJ9; Q94C09; Q9FFC8;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Transcription repressor KAN1;
DE AltName: Full=Protein KANADI 1;
GN Name=KAN1; Synonyms=KAN; OrderedLocusNames=At5g16560; ORFNames=MQK4.31;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=11395775; DOI=10.1038/35079629;
RA Kerstetter R.A., Bollman K., Taylor R.A., Bomblies K., Poethig R.S.;
RT "KANADI regulates organ polarity in Arabidopsis.";
RL Nature 411:706-709(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=11525739; DOI=10.1016/s0960-9822(01)00392-x;
RA Eshed Y., Baum S.F., Perea J.V., Bowman J.L.;
RT "Establishment of polarity in lateral organs of plants.";
RL Curr. Biol. 11:1251-1260(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=14561401; DOI=10.1016/j.cub.2003.09.035;
RA Emery J.F., Floyd S.K., Alvarez J., Eshed Y., Hawker N.P., Izhaki A.,
RA Baum S.F., Bowman J.L.;
RT "Radial patterning of Arabidopsis shoots by class III HD-ZIP and KANADI
RT genes.";
RL Curr. Biol. 13:1768-1774(2003).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15286295; DOI=10.1104/pp.104.040196;
RA Hawker N.P., Bowman J.L.;
RT "Roles for Class III HD-Zip and KANADI genes in Arabidopsis root
RT development.";
RL Plant Physiol. 135:2261-2270(2004).
RN [8]
RP FUNCTION.
RX PubMed=16623911; DOI=10.1111/j.1365-313x.2006.02717.x;
RA McAbee J.M., Hill T.A., Skinner D.J., Izhaki A., Hauser B.A., Meister R.J.,
RA Venugopala Reddy G., Meyerowitz E.M., Bowman J.L., Gasser C.S.;
RT "ABERRANT TESTA SHAPE encodes a KANADI family member, linking polarity
RT determination to separation and growth of Arabidopsis ovule integuments.";
RL Plant J. 46:522-531(2006).
RN [9]
RP FUNCTION.
RX PubMed=17307928; DOI=10.1105/tpc.106.047472;
RA Izhaki A., Bowman J.L.;
RT "KANADI and class III HD-Zip gene families regulate embryo patterning and
RT modulate auxin flow during embryogenesis in Arabidopsis.";
RL Plant Cell 19:495-508(2007).
RN [10]
RP FUNCTION, AND INDUCTION.
RX PubMed=18849474; DOI=10.1073/pnas.0803997105;
RA Wu G., Lin W.C., Huang T., Poethig R.S., Springer P.S., Kerstetter R.A.;
RT "KANADI1 regulates adaxial-abaxial polarity in Arabidopsis by directly
RT repressing the transcription of ASYMMETRIC LEAVES2.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:16392-16397(2008).
RN [11]
RP FUNCTION.
RX PubMed=20179097; DOI=10.1242/dev.047662;
RA Ilegems M., Douet V., Meylan-Bettex M., Uyttewaal M., Brand L.,
RA Bowman J.L., Stieger P.A.;
RT "Interplay of auxin, KANADI and Class III HD-ZIP transcription factors in
RT vascular tissue formation.";
RL Development 137:975-984(2010).
CC -!- FUNCTION: Transcriptional repressor that regulates lateral organ
CC polarity. Promotes lateral organ abaxial identity by repressing the
CC adaxial regulator ASYMMETRIC LEAVES2 (AS2) in abaxial cells. Required
CC for abaxial identity in both leaves and carpels. Functions with KAN2 in
CC the specification of polarity of the ovule outer integument. Regulates
CC cambium activity by repressing the auxin efflux carrier PIN1. Plays a
CC role in lateral root formation and development.
CC {ECO:0000269|PubMed:11395775, ECO:0000269|PubMed:11525739,
CC ECO:0000269|PubMed:14561401, ECO:0000269|PubMed:15286295,
CC ECO:0000269|PubMed:16623911, ECO:0000269|PubMed:17307928,
CC ECO:0000269|PubMed:18849474, ECO:0000269|PubMed:20179097}.
CC -!- INTERACTION:
CC Q93WJ9; Q9FNR3: EXO70E2; NbExp=2; IntAct=EBI-4426504, EBI-4429105;
CC Q93WJ9; Q9LQT8: GAI; NbExp=3; IntAct=EBI-4426504, EBI-963606;
CC Q93WJ9; Q9SLH3: RGA; NbExp=3; IntAct=EBI-4426504, EBI-963624;
CC Q93WJ9; Q8GXW1: RGL2; NbExp=3; IntAct=EBI-4426504, EBI-963665;
CC Q93WJ9; Q9LF53: RGL3; NbExp=3; IntAct=EBI-4426504, EBI-15681313;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in developing phloem and lateral root.
CC {ECO:0000269|PubMed:11525739, ECO:0000269|PubMed:14561401,
CC ECO:0000269|PubMed:15286295}.
CC -!- DEVELOPMENTAL STAGE: In globular embryos, expressed in the peripheral
CC cells in a basal region above the hypophysis. In heart-stage embryos,
CC expressed in the periphery of the presumptive hypocotyl and on the
CC abaxial side of cotyledon primordia. During vegetative growth,
CC expressed the abaxial side of very young leaf primordia. Expressed on
CC the abaxial side of carpel primordia and then in a localized region on
CC the abaxial margin that gives rise to the septum. Later, expressed in
CC the tissue that gives rise to ovules. {ECO:0000269|PubMed:11525739}.
CC -!- INDUCTION: Repressed by AS2 in adaxial tissue.
CC {ECO:0000269|PubMed:18849474}.
CC -!- DISRUPTION PHENOTYPE: Flat leaves. Altered morphology of abaxial
CC mesophyll cells. Decreased number of trichomes on the adaxial surface
CC and increased number of abaxial trichomes.
CC {ECO:0000269|PubMed:11395775, ECO:0000269|PubMed:11525739}.
CC -!- MISCELLANEOUS: Plants overexpressing KAN1 develop elongated and pointed
CC cotyledons and do not produced subsequent leaves, resulting in seedling
CC lethality.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09625.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY030192; AAK59989.1; -; mRNA.
DR EMBL; AY037864; AAK59990.1; -; mRNA.
DR EMBL; AY048688; AAL05436.1; -; mRNA.
DR EMBL; AB005242; BAB09625.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED92310.1; -; Genomic_DNA.
DR EMBL; BT026436; ABH04543.1; -; mRNA.
DR RefSeq; NP_568334.1; NM_121662.3.
DR AlphaFoldDB; Q93WJ9; -.
DR SMR; Q93WJ9; -.
DR BioGRID; 16794; 43.
DR IntAct; Q93WJ9; 36.
DR STRING; 3702.AT5G16560.1; -.
DR iPTMnet; Q93WJ9; -.
DR PaxDb; Q93WJ9; -.
DR PRIDE; Q93WJ9; -.
DR ProteomicsDB; 250613; -.
DR EnsemblPlants; AT5G16560.1; AT5G16560.1; AT5G16560.
DR GeneID; 831518; -.
DR Gramene; AT5G16560.1; AT5G16560.1; AT5G16560.
DR KEGG; ath:AT5G16560; -.
DR Araport; AT5G16560; -.
DR TAIR; locus:2171427; AT5G16560.
DR eggNOG; ENOG502QQZR; Eukaryota.
DR HOGENOM; CLU_047766_1_1_1; -.
DR InParanoid; Q93WJ9; -.
DR OMA; HHIEECE; -.
DR OrthoDB; 925153at2759; -.
DR PhylomeDB; Q93WJ9; -.
DR PRO; PR:Q93WJ9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q93WJ9; baseline and differential.
DR Genevisible; Q93WJ9; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0010158; P:abaxial cell fate specification; IMP:TAIR.
DR GO; GO:0009943; P:adaxial/abaxial axis specification; IMP:TAIR.
DR GO; GO:0048440; P:carpel development; IGI:TAIR.
DR GO; GO:1905392; P:plant organ morphogenesis; IMP:TAIR.
DR GO; GO:0048481; P:plant ovule development; IGI:TAIR.
DR GO; GO:0009944; P:polarity specification of adaxial/abaxial axis; IGI:TAIR.
DR GO; GO:0009956; P:radial pattern formation; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0010051; P:xylem and phloem pattern formation; IMP:TAIR.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR044847; KAN_fam.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR PANTHER; PTHR31496; PTHR31496; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..403
FT /note="Transcription repressor KAN1"
FT /id="PRO_0000408380"
FT DOMAIN 216..276
FT /note="HTH myb-type"
FT DNA_BIND 247..272
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 35..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 45845 MW; 170183B2EE9D2416 CRC64;
MSMEGVFLEK TKTNTTTTLP DLSLHISLPD IHQYHHNESS KESSRRSSQL ENNNRSSNFE
LSLSHHNHPT ARIFHCPDRR TLNLPHQQHY NNPIINGVHQ RVDESEISNL HRPIRGIPVY
HNRSFPFHQQ NSSLPSLGGG DMDQISILNS SSGYNNAYRS LQSSPRLKGV PLHHHHHHNQ
YGVVGSSDSS SPHHHNHHHH GMIRSRFLPK MPTKRSMRAP RMRWTSSLHA RFVHAVELLG
GHERATPKSV LELMDVKDLT LAHVKSHLQM YRTVKTTNKP AASSDGSGEE EMGINGNEVH
HQSSTDQRAQ SDDTSLHQET DISSTQPRWS NSSRETWPLS NNCSSDIDTM IRTSSTSMIS
HYQRSSIQNQ EQRSNDQAKR CGNLSCENPS LEFTLGRPDW HEK