KAN2_ARATH
ID KAN2_ARATH Reviewed; 388 AA.
AC Q9C616;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 139.
DE RecName: Full=Probable transcription factor KAN2;
DE AltName: Full=Protein KANADI 2;
GN Name=KAN2; OrderedLocusNames=At1g32240; ORFNames=F27G20.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=cv. Columbia;
RX PubMed=11525739; DOI=10.1016/s0960-9822(01)00392-x;
RA Eshed Y., Baum S.F., Perea J.V., Bowman J.L.;
RT "Establishment of polarity in lateral organs of plants.";
RL Curr. Biol. 11:1251-1260(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=14561401; DOI=10.1016/j.cub.2003.09.035;
RA Emery J.F., Floyd S.K., Alvarez J., Eshed Y., Hawker N.P., Izhaki A.,
RA Baum S.F., Bowman J.L.;
RT "Radial patterning of Arabidopsis shoots by class III HD-ZIP and KANADI
RT genes.";
RL Curr. Biol. 13:1768-1774(2003).
RN [7]
RP FUNCTION.
RX PubMed=15286295; DOI=10.1104/pp.104.040196;
RA Hawker N.P., Bowman J.L.;
RT "Roles for Class III HD-Zip and KANADI genes in Arabidopsis root
RT development.";
RL Plant Physiol. 135:2261-2270(2004).
RN [8]
RP FUNCTION.
RX PubMed=16623911; DOI=10.1111/j.1365-313x.2006.02717.x;
RA McAbee J.M., Hill T.A., Skinner D.J., Izhaki A., Hauser B.A., Meister R.J.,
RA Venugopala Reddy G., Meyerowitz E.M., Bowman J.L., Gasser C.S.;
RT "ABERRANT TESTA SHAPE encodes a KANADI family member, linking polarity
RT determination to separation and growth of Arabidopsis ovule integuments.";
RL Plant J. 46:522-531(2006).
RN [9]
RP FUNCTION.
RX PubMed=17307928; DOI=10.1105/tpc.106.047472;
RA Izhaki A., Bowman J.L.;
RT "KANADI and class III HD-Zip gene families regulate embryo patterning and
RT modulate auxin flow during embryogenesis in Arabidopsis.";
RL Plant Cell 19:495-508(2007).
CC -!- FUNCTION: Probable transcription factor that regulates lateral organ
CC polarity. Promotes abaxial cell fate during lateral organd formation.
CC Functions with KAN1 in the specification of polarity of the ovule outer
CC integument. {ECO:0000269|PubMed:11525739, ECO:0000269|PubMed:15286295,
CC ECO:0000269|PubMed:16623911, ECO:0000269|PubMed:17307928}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in developing phloem.
CC {ECO:0000269|PubMed:14561401}.
CC -!- MISCELLANEOUS: Plants overexpressing KAN2 develop elongated and pointed
CC cotyledons, and do not produced subsequent leaves, resulting in
CC seedling lethality.
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DR EMBL; AY048689; AAL05437.1; -; mRNA.
DR EMBL; AC084110; AAG60180.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31455.1; -; Genomic_DNA.
DR EMBL; BT029211; ABJ17146.1; -; mRNA.
DR EMBL; AB493491; BAH30329.1; -; mRNA.
DR RefSeq; NP_564392.1; NM_102957.4.
DR AlphaFoldDB; Q9C616; -.
DR SMR; Q9C616; -.
DR BioGRID; 25350; 3.
DR STRING; 3702.AT1G32240.1; -.
DR PaxDb; Q9C616; -.
DR PRIDE; Q9C616; -.
DR EnsemblPlants; AT1G32240.1; AT1G32240.1; AT1G32240.
DR GeneID; 840116; -.
DR Gramene; AT1G32240.1; AT1G32240.1; AT1G32240.
DR KEGG; ath:AT1G32240; -.
DR Araport; AT1G32240; -.
DR TAIR; locus:2028346; AT1G32240.
DR eggNOG; ENOG502QRMZ; Eukaryota.
DR HOGENOM; CLU_047766_5_0_1; -.
DR InParanoid; Q9C616; -.
DR OMA; EKDMDPK; -.
DR OrthoDB; 1076377at2759; -.
DR PhylomeDB; Q9C616; -.
DR PRO; PR:Q9C616; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C616; baseline and differential.
DR Genevisible; Q9C616; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0010158; P:abaxial cell fate specification; IEA:InterPro.
DR GO; GO:0048440; P:carpel development; IGI:TAIR.
DR GO; GO:0048481; P:plant ovule development; IGI:TAIR.
DR GO; GO:0009944; P:polarity specification of adaxial/abaxial axis; IGI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR044847; KAN_fam.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR PANTHER; PTHR31496; PTHR31496; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..388
FT /note="Probable transcription factor KAN2"
FT /id="PRO_0000408381"
FT DOMAIN 210..270
FT /note="HTH myb-type"
FT DNA_BIND 241..266
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 388 AA; 43841 MW; 05C6185E91195888 CRC64;
MELFPAQPDL SLQISPPNSK PSSTWQRRRS TTDQEDHEEL DLGFWRRALD SRTSSLVSNS
TSKTINHPFQ DLSLSNISHH QQQQQHHHPQ LLPNCNSSNI LTSFQFPTQQ QQQHLQGFLA
HDLNTHLRPI RGIPLYHNPP PHHHPHRPPP PCFPFDPSSL IPSSSTSSPA LTGNNNSFNT
SSVSNPNYHN HHHQTLNRAR FMPRFPAKRS MRAPRMRWTT TLHARFVHAV ELLGGHERAT
PKSVLELMDV KDLTLAHVKS HLQMYRTVKT TDKAAASSGQ SDVYENGSSG DNNSDDWMFD
MNRKSRDSEE LTNPLEKSNG LWTNSSGEAR LHGKLIDNVA EIMLPSEKEL DGKCSSYERI
SSEEMSSSSI SGTSPFKPNL EFTLGRSH
