KAN4_ARATH
ID KAN4_ARATH Reviewed; 276 AA.
AC Q9FJV5; B3H696;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Probable transcription factor KAN4;
DE AltName: Full=Protein ABERRANT TESTA SHAPE;
DE AltName: Full=Protein KANADI 4;
GN Name=KAN4; Synonyms=ATS; OrderedLocusNames=At5g42630; ORFNames=MFO20.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=11525739; DOI=10.1016/s0960-9822(01)00392-x;
RA Eshed Y., Baum S.F., Perea J.V., Bowman J.L.;
RT "Establishment of polarity in lateral organs of plants.";
RL Curr. Biol. 11:1251-1260(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=15286295; DOI=10.1104/pp.104.040196;
RA Hawker N.P., Bowman J.L.;
RT "Roles for Class III HD-Zip and KANADI genes in Arabidopsis root
RT development.";
RL Plant Physiol. 135:2261-2270(2004).
RN [6]
RP FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
RP PRO-133.
RX PubMed=16623911; DOI=10.1111/j.1365-313x.2006.02717.x;
RA McAbee J.M., Hill T.A., Skinner D.J., Izhaki A., Hauser B.A., Meister R.J.,
RA Venugopala Reddy G., Meyerowitz E.M., Bowman J.L., Gasser C.S.;
RT "ABERRANT TESTA SHAPE encodes a KANADI family member, linking polarity
RT determination to separation and growth of Arabidopsis ovule integuments.";
RL Plant J. 46:522-531(2006).
RN [7]
RP FUNCTION.
RX PubMed=19054366; DOI=10.1111/j.1365-313x.2008.03752.x;
RA Kelley D.R., Skinner D.J., Gasser C.S.;
RT "Roles of polarity determinants in ovule development.";
RL Plant J. 57:1054-1064(2009).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, AND ALTERNATIVE SPLICING.
RX PubMed=20444210; DOI=10.1111/j.1467-7652.2010.00525.x;
RA Gao P., Li X., Cui D., Wu L., Parkin I., Gruber M.Y.;
RT "A new dominant Arabidopsis transparent testa mutant, sk21-D, and
RT modulation of seed flavonoid biosynthesis by KAN4.";
RL Plant Biotechnol. J. 8:979-993(2010).
CC -!- FUNCTION: Probable transcription factor that regulates carpel
CC integuments formation. Required for the specification of polarity in
CC the ovule inner integument. Modulates the content of flavonols and
CC proanthocyanidin in seeds. {ECO:0000269|PubMed:16623911,
CC ECO:0000269|PubMed:19054366, ECO:0000269|PubMed:20444210}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20444210}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FJV5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FJV5-2; Sequence=VSP_041078, VSP_041079;
CC -!- TISSUE SPECIFICITY: Expressed in the periphery of the primary root apex
CC and lateral root. {ECO:0000269|PubMed:15286295}.
CC -!- DEVELOPMENTAL STAGE: During ovule development, first expressed in the
CC inner integument primordium and then on the abaxial side of the inner
CC integument. {ECO:0000269|PubMed:16623911}.
CC -!- DISRUPTION PHENOTYPE: Ovules with a single integument instead of two.
CC {ECO:0000269|PubMed:16623911}.
CC -!- MISCELLANEOUS: Plants overexpressing KAN4 show reduced or absent ovule
CC outer integument and color alteration of the seed coat.
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DR EMBL; AB013391; BAB10501.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94838.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94839.1; -; Genomic_DNA.
DR EMBL; AY048691; AAL05439.1; -; mRNA.
DR EMBL; BT026053; ABG48409.1; -; mRNA.
DR RefSeq; NP_001119363.1; NM_001125891.2. [Q9FJV5-2]
DR RefSeq; NP_199077.1; NM_123627.3. [Q9FJV5-1]
DR AlphaFoldDB; Q9FJV5; -.
DR SMR; Q9FJV5; -.
DR BioGRID; 19520; 10.
DR IntAct; Q9FJV5; 7.
DR STRING; 3702.AT5G42630.1; -.
DR PaxDb; Q9FJV5; -.
DR PRIDE; Q9FJV5; -.
DR EnsemblPlants; AT5G42630.1; AT5G42630.1; AT5G42630. [Q9FJV5-1]
DR EnsemblPlants; AT5G42630.2; AT5G42630.2; AT5G42630. [Q9FJV5-2]
DR GeneID; 834270; -.
DR Gramene; AT5G42630.1; AT5G42630.1; AT5G42630. [Q9FJV5-1]
DR Gramene; AT5G42630.2; AT5G42630.2; AT5G42630. [Q9FJV5-2]
DR KEGG; ath:AT5G42630; -.
DR Araport; AT5G42630; -.
DR TAIR; locus:2163852; AT5G42630.
DR eggNOG; ENOG502R498; Eukaryota.
DR InParanoid; Q9FJV5; -.
DR OMA; GRPSWGM; -.
DR OrthoDB; 1140698at2759; -.
DR PhylomeDB; Q9FJV5; -.
DR PRO; PR:Q9FJV5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJV5; baseline and differential.
DR Genevisible; Q9FJV5; AT.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR GO; GO:0010158; P:abaxial cell fate specification; IEA:InterPro.
DR GO; GO:0080060; P:integument development; IMP:UniProtKB.
DR GO; GO:0048481; P:plant ovule development; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR044847; KAN_fam.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR PANTHER; PTHR31496; PTHR31496; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Differentiation; DNA-binding;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..276
FT /note="Probable transcription factor KAN4"
FT /id="PRO_0000408383"
FT DOMAIN 102..162
FT /note="HTH myb-type"
FT DNA_BIND 133..158
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 30..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 210..223
FT /note="ASWSSTKEVSRSIS -> LLFIYIFIFVKFCI (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_041078"
FT VAR_SEQ 224..276
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_041079"
FT MUTAGEN 133
FT /note="P->L: In ats-2; ovules with a single integument."
FT /evidence="ECO:0000269|PubMed:16623911"
SQ SEQUENCE 276 AA; 30961 MW; 30FC1700B6D97A13 CRC64;
MMMLESRNSM RASNSVPDLS LQISLPNYHA GKPLHGGDRS STSSDSGSSL SDLSHENNFF
NKPLLSLGFD HHHQRRSNMF QPQIYGRDFK RSSSSMVGLK RSIRAPRMRW TSTLHAHFVH
AVQLLGGHER ATPKSVLELM NVKDLTLAHV KSHLQMYRTV KCTDKGSPGE GKVEKEAEQR
IEDNNNNEEA DEGTDTNSPN SSSVQKTQRA SWSSTKEVSR SISTQAYSHL GTTHHTKDNE
EKEDTNIHLN LDFTLGRPSW GMEYAEPSSD LTLLKC