ID   KANL2_PONAB             Reviewed;         492 AA.
AC   Q5R802;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=KAT8 regulatory NSL complex subunit 2;
DE   AltName: Full=NSL complex protein NSL2;
DE   AltName: Full=Non-specific lethal 2 homolog;
GN   Name=KANSL2; Synonyms=NSL2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of the NSL complex it is involved in acetylation of
CC       nucleosomal histone H4 on several lysine residues and therefore may be
CC       involved in the regulation of transcription. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NSL complex at least composed of MOF/KAT8,
CC       KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR859954; CAH92108.1; -; mRNA.
DR   RefSeq; NP_001126230.1; NM_001132758.2.
DR   AlphaFoldDB; Q5R802; -.
DR   STRING; 9601.ENSPPYP00000005096; -.
DR   GeneID; 100173200; -.
DR   KEGG; pon:100173200; -.
DR   CTD; 54934; -.
DR   eggNOG; ENOG502QTMA; Eukaryota.
DR   InParanoid; Q5R802; -.
DR   OrthoDB; 172254at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0000123; C:histone acetyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.
DR   GO; GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
DR   GO; GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
DR   InterPro; IPR026316; NSL2.
DR   InterPro; IPR025927; Potential_DNA-bd.
DR   PANTHER; PTHR13453; PTHR13453; 1.
DR   Pfam; PF13891; zf-C3Hc3H; 2.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Isopeptide bond; Nucleus; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..492
FT                   /note="KAT8 regulatory NSL complex subunit 2"
FT                   /id="PRO_0000278294"
FT   REGION          127..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..492
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         131
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9L4"
FT   MOD_RES         147
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9L4"
FT   MOD_RES         149
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9L4"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AY70"
FT   MOD_RES         172
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AY70"
FT   MOD_RES         175
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AY70"
FT   CROSSLNK        78
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9L4"
SQ   SEQUENCE   492 AA;  55052 MW;  102F1A8058EDF3D4 CRC64;
     MNRIRIHVLP TNRGRITPVP RSQEPLSCAF THRPCSQPRL EGQEFCIKHI LEDKDAPFKQ
     CSYISTKNGK RCPNAAPKPE KKDGVSFCAE HVRRNALALH AQMKKTNPGP MGETLLCQLS
     SYAKTELGSQ TPESSRSEAS RILDEDSWSD GEQEPITVDQ TWRGDPDSEA DSIDSDQEDP
     LKHAGVYTAE EVALIMREKL IRLQSLYIDQ FKRLQHLLKE KKRRYLHNRK VEHEALGSSL
     LTGPEGLLAK ERENLKRLKC LRRYRQRYGV EALLHRQLKE RRMLATDGAA QQAHTTRSSQ
     RCLAFVDDVR CSNQSLPMTR HCLTHICQDT NQVLFKCCQG SEEVPCNKPV PVSLSEDPCC
     PLHFQLPPQM YKPEQVLSVP DDLEAGPMDL YLSAAELQPT ESLPLEFSDD LDVVGDGMQC
     PPSPLLFDPS LTLEDHLVKE IAEDPVDILG QMQMAGDGCR SQGSRNSEKG SAPLSQSGLA
     TANGKPEPTS IS