KANL2_RAT
ID KANL2_RAT Reviewed; 488 AA.
AC Q6AY70; G3V7H0;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=KAT8 regulatory NSL complex subunit 2;
DE AltName: Full=NSL complex protein NSL2;
DE AltName: Full=Non-specific lethal 2 homolog;
GN Name=Kansl2; Synonyms=Nsl2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147; SER-149; SER-168;
RP SER-172 AND SER-175, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: As part of the NSL complex it is involved in acetylation of
CC nucleosomal histone H4 on several lysine residues and therefore may be
CC involved in the regulation of transcription. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NSL complex at least composed of MOF/KAT8,
CC KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6AY70-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6AY70-2; Sequence=VSP_042534, VSP_042535;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH79169.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; CH474035; EDL87055.1; -; Genomic_DNA.
DR EMBL; BC079169; AAH79169.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001004244.2; NM_001004244.2. [Q6AY70-1]
DR RefSeq; XP_008763913.1; XM_008765691.1. [Q6AY70-1]
DR RefSeq; XP_008763914.1; XM_008765692.2. [Q6AY70-1]
DR RefSeq; XP_008763915.1; XM_008765693.2. [Q6AY70-1]
DR RefSeq; XP_008763916.1; XM_008765694.2.
DR RefSeq; XP_008764075.1; XM_008765853.2. [Q6AY70-1]
DR RefSeq; XP_008764076.1; XM_008765854.2. [Q6AY70-1]
DR RefSeq; XP_008764077.1; XM_008765855.2. [Q6AY70-1]
DR RefSeq; XP_008764078.1; XM_008765856.2.
DR RefSeq; XP_008764079.1; XM_008765857.1.
DR AlphaFoldDB; Q6AY70; -.
DR SMR; Q6AY70; -.
DR STRING; 10116.ENSRNOP00000014875; -.
DR iPTMnet; Q6AY70; -.
DR PhosphoSitePlus; Q6AY70; -.
DR PaxDb; Q6AY70; -.
DR PRIDE; Q6AY70; -.
DR Ensembl; ENSRNOT00000086886; ENSRNOP00000073779; ENSRNOG00000060185. [Q6AY70-1]
DR Ensembl; ENSRNOT00000090730; ENSRNOP00000072729; ENSRNOG00000060185. [Q6AY70-2]
DR GeneID; 300206; -.
DR KEGG; rno:300206; -.
DR UCSC; RGD:1303127; rat. [Q6AY70-1]
DR CTD; 54934; -.
DR RGD; 1303127; Kansl2.
DR eggNOG; ENOG502QTMA; Eukaryota.
DR GeneTree; ENSGT00940000155808; -.
DR InParanoid; Q6AY70; -.
DR OrthoDB; 172254at2759; -.
DR TreeFam; TF324169; -.
DR Reactome; R-RNO-3214847; HATs acetylate histones.
DR PRO; PR:Q6AY70; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Proteomes; UP000234681; Chromosome 7.
DR GO; GO:0000123; C:histone acetyltransferase complex; ISS:UniProtKB.
DR GO; GO:0044545; C:NSL complex; ISO:RGD.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.
DR GO; GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
DR GO; GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
DR GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; ISO:RGD.
DR GO; GO:1900095; P:regulation of dosage compensation by inactivation of X chromosome; ISO:RGD.
DR InterPro; IPR026316; NSL2.
DR InterPro; IPR025927; Potential_DNA-bd.
DR PANTHER; PTHR13453; PTHR13453; 1.
DR Pfam; PF13891; zf-C3Hc3H; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromatin regulator; Isopeptide bond; Nucleus;
KW Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN 1..488
FT /note="KAT8 regulatory NSL complex subunit 2"
FT /id="PRO_0000278295"
FT REGION 127..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 131
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9L4"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 149
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 168
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 172
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT CROSSLNK 78
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9H9L4"
FT VAR_SEQ 145..157
FT /note="EDSWSDGDQEPIT -> MRVSIQPRRWLLS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042534"
FT VAR_SEQ 158..488
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042535"
SQ SEQUENCE 488 AA; 54378 MW; AA9563622D63842E CRC64;
MNRIRIHVLP TNRGRITPVP RSQEPLSCSF THRPCSQPRL EGQEFCLKHI LEDKNAPFKQ
CSYISTKNGK RCPSAAPKPE KKDGVSFCAE HARRNALALH AQMKKSNPGP MGETLLCQLS
SYAKTELGSQ TPESSRSEAS RILDEDSWSD GDQEPITVDQ TWRGDPDSEA DSIDSDQEDP
LKHAGVYTAE EVALIMREKL IRLQSLYIDQ FKRLQHLLKE KKRRYLHNRK VEHEALGSSL
LTGPEGLLAK ERENLKRLKC LRRYRQRYGV EALLHRQLKE RRMLATEGAA QQAHTTRSSQ
RCLAFVDDVR CSNQSLPMTR HCLTHICQDT NQVLFKCCQG SEEVPCNKPV PVSLSEDPCC
PLHFQLPPQM YKPEQVLSVP DGLEAGPMDL YLSAAELQPT ESLPLELSDD LDVVGDGMPC
PPSPLLFDPS LTLEDHSVTE IAGGPGQIQV AGDGCRSQGP HNVEKTCAPF PQRGLATANG
KPEPTSIS
